| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Cathepsin C/DPP1 |
| Specificity: |
This antibody reacts specifically with Cathepsin C/DPP1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human DPP-I |
| Gene ID: |
1075 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, It is composed of a dimer of disulfide-linked heavy and light chains, Multiple transcript variants encoding different isoforms have been found for this gene, This enzyme requires chloride ions for activity and can degrade glucagon, [provided by RefSeq], a member of the peptidase C1 family, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme, both produced from a single protein precursor, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells, The protein encoded by this gene |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
DPP1 |
| Also known as: |
Cathepsin C/DPP1 Polyclonal Antibody |
| Other name: |
Anti-Cathepsin C/DPP1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene: |
CTSC |
More about : CTSC |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Cathepsin C/DPP1 |
| Short name: |
Anti-Cathepsin C/DPP1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Cathepsin C/DPP1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
2528 |
| Long gene name: |
cathepsin C |
| Synonyms gene: |
PLS PALS |
| Synonyms name: |
dipeptidyl peptidase 1 |
| Locus: |
11q14, 2 |
| Discovery year: |
1995-11-08 |
| GenBank acession: |
AK223038 |
| Entrez gene record: |
1075 |
| Pubmed identfication: |
7649281 9092576 |
| RefSeq identity: |
NM_001814 |
| Classification: |
Cathepsins |
| Havana BLAST/BLAT: |
OTTHUMG00000167290 |
| Locus Specific Databases: |
CTSCbase: Mutation registry for Papillon-Lefevre syndrome LRG_50 |