| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
IL-17C |
| Specificity: |
This antibody reacts specifically with IL-17C |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human IL-17C |
| Gene ID: |
27189 |
| Swiss Prot: |
Q9P0M4 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts synergically with IL22 in inducing the expression of antibacterial peptides, Depending on the type of insult, Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases, REG3A and REG3G, S100A9, Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways, Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype, in an autocrine manner, including S100A8, including to intestinal bacterial pathogens, may have both protective and pathogenic properties, Cytokine that plays a crucial role in innate immunity of the epithelium |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
IL-17C CX2 IL-21 MGC126884 MGC138401 |
| Also known as: |
IL-17C Polyclonal Antibody |
| Other name: |
Anti-IL-17C Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
IL-17C |
| Short name: |
Anti-IL-17C (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Interleukin-17C (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
5983 |
| Gene: |
IL17C |
More about : IL17C |
| Long gene name: |
interleukin 17C |
| Locus: |
16q24, 2 |
| Discovery year: |
2000-01-20 |
| GenBank acession: |
AF152099 |
| Entrez gene record: |
27189 |
| Pubmed identfication: |
10639155 |
| RefSeq identity: |
NM_013278 |
| Classification: |
Interleukins |
| Havana BLAST/BLAT: |
OTTHUMG00000173241 |