| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
GLUR3/GRIA 3 |
| Specificity: |
This antibody reacts specifically with GLUR3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human GLUR3 |
| Gene ID: |
2892 |
| Swiss Prot: |
P42263 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, In the presence of CACNG4 or CACNG7 or CACNG8, L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system, The receptor then desensitizes rapidly and enters a transient inactive state, and thereby converts the chemical signal to an electrical impulse, characterized by the presence of bound agonist, leading to the opening of the cation channel, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate, Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
GluA3 GLURC MRX94 |
| Also known as: |
GLUR3 Polyclonal Antibody |
| Other name: |
Anti-GLUR3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
GLUR3 |
| Short name: |
Anti-GLUR3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-GLUR3 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4573 |
| Gene: |
GRIA3 |
More about : GRIA3 |
| Long gene name: |
glutamate ionotropic receptor AMPA type subunit 3 |
| Synonyms gene: |
GLUR3 |
| Synonyms gene name: |
AMPA 3 , glutamate receptor, ionotrophic |
| Locus: |
Xq25 |
| Discovery year: |
1992-02-26 |
| GenBank acession: |
U10301 |
| Entrez gene record: |
2892 |
| Pubmed identfication: |
1319477 10644433 |
| RefSeq identity: |
NM_000828 |
| Classification: |
Glutamate ionotropic receptor AMPA type subunits X-linked mental retardation |
| Havana BLAST/BLAT: |
OTTHUMG00000022685 |
| Locus Specific Databases: |
Mental Retardation database |