| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
FDC-SP |
| Specificity: |
This antibody reacts specifically with FDC-SP |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from rat FDC-SP |
| Gene ID: |
494224 |
| Swiss Prot: |
Q5R1M6 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
B cells form germinal centers around follicular dendritic cells in lymphoid organs, Dendritic cells form from monocytes, Evidence in pathological tissue and functional studies suggests it binds to an epitope expressed by antigen presenting cells, It is purely a resident of the follicles of secondary lymphoid organs, The monocytes in turn are formed from stem cells in the bone marrow, This kind of dendritic cell is not bone marrow derived and is not a kind of blood cell, Within the macrophage/dendritic cell populations the epitope seen by RFD1 is coexpressed with RFD7 by a subset of cells that exhibit suppressive activity on T cell stimulation, can turn into dendritic cells or macrophages, depending on the right signal, white blood cells which circulate in the body and, Follicular dendritic cells are cells that facilitate antigen recognition by B cells in follicles, In normal tissue this antibody identifies dendritic cells and a proportion of B lymphocytes |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FDC-SP |
| Also known as: |
FDC-SP Polyclonal Antibody |
| Other name: |
Anti-FDC-SP Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
FDC-SP |
| Short name: |
Anti-FDC-SP (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-FDC-SP (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
19215 |
| Gene: |
FDCSP |
More about : FDCSP |
| Long gene name: |
follicular dendritic cell secreted protein |
| Synonyms gene: |
C4orf7 |
| Synonyms gene name: |
chromosome 4 open reading frame 7 |
| Locus: |
4q13, 3 |
| Discovery year: |
2002-09-17 |
| GenBank acession: |
AF435080 |
| Entrez gene record: |
260436 |
| Pubmed identfication: |
12193705 17548624 20811673 |
| RefSeq identity: |
NM_152997 |
| Havana BLAST/BLAT: |
OTTHUMG00000129393 |