| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Glucose 6 phosphatase 2/IGRP |
| Specificity: |
This antibody reacts specifically with Glucose 6 phosphatase 2/IGRP |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Glucose 6 phosphatase 2/IGRP |
| Gene ID: |
57818 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
G6Pase localizes to the endoplasmic reticulum, G6Pase-alpha, IGRP has been shown to be a glycoprotein held in the endoplasmic reticulum by nine transmembrane domains, Identification of inhibitors of IGRP have potential therapeutic benefits for treatment of type 2 diabetes resulting from insulin secretion defects, Islet-specific G-6-Pase catalytic subunit-related protein (IGRP), Structurally, The exact catalytic acivity of IGRP is not defined, a homolog of the catalytic subunit of G6Pase, a second form, and intestine are the only tissues that express the first identified isoform, and while liver, contributes to blood glucose homeostasis in a wider range of tissues, designated G6Pase-â, is a multicomponent enzyme system that hydrolyzes glucose-6-phosphate in the final step of gluconeogenesis and gluconeolysis, kidney, may play a role in the regulation of islet metabolism and in insulin secretion induced by metabolites, which are then degraded in cells through the proteasome pathway generating MHC class I presented peptides, &circ, «, Glucose-6-phosphatase (G6Pase) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
IGRP |
| Also known as: |
Glucose 6 phosphatase 2/IGRP Antibody |
| Other name: |
Anti-Glucose 6 phosphatase 2/IGRP |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Glucose 6 phosphatase 2/IGRP |
| Short name: |
Fluor 594, Anti-Glucose 6 phosphatase 2/IGRP |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Glucose 6 phosphatase 2/IGRP |
| Identity: |
28906 |
| Gene: |
G6PC2 |
More about : G6PC2 |
| Long gene name: |
glucose-6-phosphatase catalytic subunit 2 |
| Synonyms gene name: |
2 , catalytic, glucose-6-phosphatase |
| Synonyms name: |
islet specific glucose 6 phosphatase catalytic subunit related protein |
| Locus: |
2q31, 1 |
| Discovery year: |
2004-03-29 |
| GenBank acession: |
AF283575 |
| Entrez gene record: |
57818 |
| Pubmed identfication: |
10078553 10078554 |
| RefSeq identity: |
NM_021176 |
| Classification: |
Glucose 6-phosphatases, catalytic |
| Havana BLAST/BLAT: |
OTTHUMG00000132182 |