| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
FDPS |
| Specificity: |
This antibody reacts specifically with FDPS |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human FDPS |
| Gene ID: |
2224 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Existing as a homodimer, FDPS assists in cholesterol biosynthesis, FDPS expression is regulated by phorbol esters and polyunsaturated fatty acids, FDPS is inactivated by interferon-induced RSAD2, FDPS may have anti-viral effects when inactivated by RSAD2, Localized to cytoplasm and peroxisome, Reduced activity of FDPS in liver may partly be the cause of Zellweger syndrome and neonatal adrenoleukodystrophy, a precursor for several classes of essential metabolites including sterols, and ubiquinones, both of which are known to be peroxisomal deficiency diseases, carotenoids, dolichols, post-translational protein modifications and synthesis of steroid hormones in the isoprenoid pathway, which may result in the disruption of lipid rafts at the plasma membrane, FDPS catalyzes the formation of farnesyl diphosphate (FPP), FDPS is a 419 amino acid enzyme belonging to the FPP/GGPP synthetase family |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
FDPS Polyclonal Antibody |
| Other name: |
Anti-FDPS Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
FDPS |
| Short name: |
Anti-FDPS (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-FDPS (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
3631 |
| Gene: |
FDPS |
More about : FDPS |
| Long gene name: |
farnesyl diphosphate synthase |
| Synonyms name: |
dimethylallyltranstransferase, farnesyl pyrophosphate synthetase, geranyltranstransferase |
| Locus: |
1q22 |
| Discovery year: |
1992-03-13 |
| GenBank acession: |
J05262 |
| Entrez gene record: |
2224 |
| Pubmed identfication: |
1968462 |
| RefSeq identity: |
NM_002004 |
| Havana BLAST/BLAT: |
OTTHUMG00000013909 |