| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HAP40/F8a |
| Specificity: |
This antibody reacts specifically with HAP40/F8a |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human HAP40 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
HAP40, HAP40 mediates the recruitment of Huntingtin by Rab5 onto early endosomes, Huntingtin interacts with a variety of proteins including HAP1, Rab5 and HIP1, Specifically, The loss of activity of the Huntingtin protein may be contributed to abnormal interactions between the mutant protein and other associated cellular proteins, The mutated Huntingtin protein acts within the nucleus to induce neurodegeneration by a cell-specific apoptotic mechanism, glyceraldehyde phosphate dehydrogenase (GAPDH), this complex regulates endosome motility, which leads to Huntingtinâ, which may be a key event of the pathogenetic process leading to neurodegeneration in HD, &euro, &trade, The Huntingtin protein contains a polyglutamine region, s disease (HD) when the number of glutamine repeats exceeds thirty-five |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Coagulation factor VIII associated intronic transcript 1, CpG island protein, DXS522E, F8A1, F8A2, F8A3, F8I2_HUMAN, F8a, Factor 8 associated protein, Factor 8 intron 22 protein, Factor VIII associated protein, Factor VIII intron 22 protein, huntingtin associated protein 40, Coagulation factor 8 associated intronic transcript 1 |
| Also known as: |
HAP40/F8a Polyclonal Antibody |
| Other name: |
Anti-HAP40/F8a Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HAP40/F8a |
| Short name: |
Anti-HAP40/F8a (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-HAP40/F8a (polyclonal) |
| Alternative technique: |
polyclonals |