| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HSD17B4 |
| Specificity: |
This antibody reacts specifically with HSD17B4 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human HSD17B4 Enoyl-CoA hydratase 2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
17Beta-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol Beta-oxidation, 17Beta-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6, 17Beta-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life, D-bifunctional enzyme or 17-Beta Estradiol dehydrogenase type IV, It belongs to the 17Beta-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body, It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain, They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period, 17Beta-HSD4 (17Beta-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MFE-2 DBP SDR8C1 |
| Also known as: |
HSD17B4 Polyclonal Antibody |
| Other name: |
Anti-HSD17B4 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HSD17B4 |
| Short name: |
Anti-HSD17B4 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-HSD17B4 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
5213 |
| Gene: |
HSD17B4 |
More about : HSD17B4 |
| Long gene name: |
hydroxysteroid 17-beta dehydrogenase 4 |
| Synonyms gene name: |
hydroxysteroid (17-beta) dehydrogenase 4 |
| Synonyms name: |
17beta-estradiol dehydrogenase type IV peroxisomal multifunctional protein 2 17-beta-HSD IV 17-beta-hydroxysteroid dehydrogenase 4 D-bifunctional protein, member 1 , peroxisomal D-3-hydroxyacyl-CoA dehydratase 3-alpha, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase beta-keto-reductase beta-hydroxyacyl dehydrogenase short chain dehydrogenase/reductase family 8C, 7-alpha |
| Locus: |
5q23, 1 |
| Discovery year: |
1994-09-14 |
| Entrez gene record: |
3295 |
| Pubmed identfication: |
8938456 19027726 |
| RefSeq identity: |
NM_000414 |
| Classification: |
Short chain dehydrogenase/reductase superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000128899 |