| Long name: |
HSD17B4 Primary Polyclonal Antibody |
| Also known as: |
HSD17B4 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HSD17B4 |
| Specificity: |
This is a highly specific antibody against HSD17B4 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HSD17B4 Enoyl-CoA hydratase 2 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
17Beta-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol Beta-oxidation, 17Beta-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6, 17Beta-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life, D-bifunctional enzyme or 17-Beta Estradiol dehydrogenase type IV, It belongs to the 17Beta-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body, It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain, They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period, 17Beta-HSD4 (17Beta-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase, 17 beta HSD 4, 17 beta HSD IV, 17 beta hydroxysteroid dehydrogenase 4, 17-beta-HSD 4, 17-beta-hydroxysteroid dehydrogenase 4, 17beta estradiol dehydrogenase type IV, 3 alpha 7 alpha12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase antibody 3-alpha, 7-alpha, Beta hydroxyacyl dehydrogenase, Beta keto reductase, D 3 hydroxyacyl CoA dehydratase, D bunctional protein, D bunctional protein peroxisomal, D-bunctional protein, DBP, DHB4_HUMAN, EDH17B4, Enoyl-CoA hydratase 2, Hsd17b4, MFE 2, MFE-2, MPF-2, Multunctional protein 2, Peroxisomal multunctional enzyme type 2, Peroxisomal multunctional protein 2, SDR8C1, Short chain dehydrogenase/reductase family 8C member 1, hydroxysteroid 17-beta dehydrogenase 4 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HSD17B4 |
| Short name: |
HSD17B4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HSD17B4 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5213 |
| Gene: |
HSD17B4 |
More about : HSD17B4 |
| Long gene name: |
hydroxysteroid 17-beta dehydrogenase 4 |
| Synonyms gene name: |
hydroxysteroid (17-beta) dehydrogenase 4 |
| Synonyms: |
MFE-2 DBP SDR8C1 |
| Synonyms name: |
17beta-estradiol dehydrogenase type IV peroxisomal multifunctional protein 2 17-beta-HSD IV 17-beta-hydroxysteroid dehydrogenase 4 D-bifunctional protein, member 1 , peroxisomal D-3-hydroxyacyl-CoA dehydratase 3-alpha, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase beta-keto-reductase beta-hydroxyacyl dehydrogenase short chain dehydrogenase/reductase family 8C, 7-alpha |
| Locus: |
5q23, 1 |
| Discovery year: |
1994-09-14 |
| Entrez gene record: |
3295 |
| Pubmed identfication: |
8938456 19027726 |
| RefSeq identity: |
NM_000414 |
| Classification: |
Short chain dehydrogenase/reductase superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000128899 |