| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SYVN1 |
| Specificity: |
This antibody reacts specifically with SYVN1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SYVN1 |
| Gene ID: |
84447 |
| Swiss Prot: |
Q86TM6 |
| Applications: |
IF(IHC-F), IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-F)(1:50-200), IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Also promotes the degradation of normal but naturally short-lived proteins such as SGK, Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins, Protects cells from ER stress-induced apoptosis, Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation, Sequesters p53/TP53 in the cytoplasm and promotes its degradation, cell cycle regulation and apoptosis, promoting their degradation, thereby negatively regulating its biological function in transcription, Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
HRD1 DER3 |
| Also known as: |
SYVN1 Polyclonal Antibody |
| Other name: |
Anti-SYVN1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SYVN1 |
| Short name: |
Anti-SYVN1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, synoviolin (polyclonal), antibody to-synovial apoptosis inhibitor 1 |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BT, SYVN1 and IDBG-56611 and ENSG00000162298 and 102465449, Syvn1 and IDBG-134090 and ENSMUSG00000024807 and 74126, metal ion binding, nuclei, synoviolin, this GO :0001701 and in utero embryonic development and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0006987 and activation of signaling protein activity involved in unfolded protein response and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016567 and protein ubiquitination and biological process this GO :0016881 and acid-amino acid ligase activity and molecular function this GO :0018279 and protein N-linked glycosylation via asparagine and biological process this GO :0030433 and ER-associated ubiquitin-dependent protein catabolic process and biological process this GO :0030968 and endoplasmic reticulum unfolded protein response and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0046872 and metal ion binding and molecular function this GO :1902236 and negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0016881 : acid-amino acid ligase activity and also this GO :0046872 : metal ion binding, this GO :0008270 : zinc ion binding, this GO :0016881 : acid-amino acid ligase activity, this GO :0046872 : metal ion binding, 54995 and IDBG-644142 and ENSBTAG00000005076 and 508358, 84447, synovial apoptosis inhibitor 1 |
| Identity: |
20738 |
| Gene: |
SYVN1 |
More about : SYVN1 |
| Long gene name: |
synoviolin 1 |
| Synonyms gene name: |
synovial apoptosis inhibitor 1, synoviolin |
| Synonyms name: |
HMG-coA reductase degradation 1 homolog (S, cerevisiae) |
| Locus: |
11q13, 1 |
| Discovery year: |
2004-07-28 |
| GenBank acession: |
AB085847 |
| Entrez gene record: |
84447 |
| Pubmed identfication: |
12975321 |
| RefSeq identity: |
NM_032431 |
| Classification: |
Ring finger proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000165607 |