| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SYVN1 (HRD1) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB, IF |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:200-1000 |
| Notes: |
Titration of the SYVN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This SYVN1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q86TM6 |
| Purity: |
Purified |
| Description: |
Amano T, Expression of SYVN1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum, It is expressed in many tissues, et al, kidney and skeletal muscle, liver, pancreas, reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects, strongly expressed in brain, HRD1/SYVN1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress |
| Immunogen: |
A portion of amino acids 586-617 from the human protein was used as the immunogen for this SYVN1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SYVN1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SYVN1 (HRD1) |
| Short name: |
SYVN1 Antibody (HRD1) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
synoviolin (Antibody to) (HRD1), synovial apoptosis inhibitor 1 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, SYVN1 and IDBG-56611 and ENSG00000162298 and 102465449, Syvn1 and IDBG-134090 and ENSMUSG00000024807 and 74126, metal ion binding, nuclei, synoviolin, this GO :0001701 and in utero embryonic development and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0006987 and activation of signaling protein activity involved in unfolded protein response and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016567 and protein ubiquitination and biological process this GO :0016881 and acid-amino acid ligase activity and molecular function this GO :0018279 and protein N-linked glycosylation via asparagine and biological process this GO :0030433 and ER-associated ubiquitin-dependent protein catabolic process and biological process this GO :0030968 and endoplasmic reticulum unfolded protein response and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0046872 and metal ion binding and molecular function this GO :1902236 and negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0016881 : acid-amino acid ligase activity and also this GO :0046872 : metal ion binding, this GO :0008270 : zinc ion binding, this GO :0016881 : acid-amino acid ligase activity, this GO :0046872 : metal ion binding, 54995 and IDBG-644142 and ENSBTAG00000005076 and 508358, 84447, synovial apoptosis inhibitor 1 |
| Identity: |
20738 |
| Gene: |
SYVN1 |
More about : SYVN1 |
| Long gene name: |
synoviolin 1 |
| Synonyms gene name: |
synovial apoptosis inhibitor 1, synoviolin |
| Synonyms: |
HRD1 DER3 |
| Synonyms name: |
HMG-coA reductase degradation 1 homolog (S, cerevisiae) |
| Locus: |
11q13, 1 |
| Discovery year: |
2004-07-28 |
| GenBank acession: |
AB085847 |
| Entrez gene record: |
84447 |
| Pubmed identfication: |
12975321 |
| RefSeq identity: |
NM_032431 |
| Classification: |
Ring finger proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000165607 |