| Category: |
Antibody |
| Concentration: |
09% sodium azide, 4 with 0, In 1X PBS pH 7 |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SYVN1 (HRD1) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the HRD1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This HRD1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q86TM6 |
| Purity: |
Purified |
| Description: |
Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum, HRD1 contains one ring-type zinc finger, HRD1 is expressed in many tissues, Synoviolin/Hrd1 (expressed in rheumatoid synovium) is reported to be a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects, kidney and skeletal muscle, liver, pancreas, strongly expressed in brain, HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress |
| Immunogen: |
A portion of amino acids 58-88 from the human protein was used as the immunogen for this HRD1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the HRD1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SYVN1 (HRD1) |
| Short name: |
SYVN1 Antibody (HRD1) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
synoviolin (Antibody to) (HRD1), synovial apoptosis inhibitor 1 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, SYVN1 and IDBG-56611 and ENSG00000162298 and 102465449, Syvn1 and IDBG-134090 and ENSMUSG00000024807 and 74126, metal ion binding, nuclei, synoviolin, this GO :0001701 and in utero embryonic development and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0006987 and activation of signaling protein activity involved in unfolded protein response and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016567 and protein ubiquitination and biological process this GO :0016881 and acid-amino acid ligase activity and molecular function this GO :0018279 and protein N-linked glycosylation via asparagine and biological process this GO :0030433 and ER-associated ubiquitin-dependent protein catabolic process and biological process this GO :0030968 and endoplasmic reticulum unfolded protein response and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0046872 and metal ion binding and molecular function this GO :1902236 and negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0016881 : acid-amino acid ligase activity and also this GO :0046872 : metal ion binding, this GO :0008270 : zinc ion binding, this GO :0016881 : acid-amino acid ligase activity, this GO :0046872 : metal ion binding, 54995 and IDBG-644142 and ENSBTAG00000005076 and 508358, 84447, synovial apoptosis inhibitor 1 |
| Identity: |
20738 |
| Gene: |
SYVN1 |
More about : SYVN1 |
| Long gene name: |
synoviolin 1 |
| Synonyms gene name: |
synovial apoptosis inhibitor 1, synoviolin |
| Synonyms: |
HRD1 DER3 |
| Synonyms name: |
HMG-coA reductase degradation 1 homolog (S, cerevisiae) |
| Locus: |
11q13, 1 |
| Discovery year: |
2004-07-28 |
| GenBank acession: |
AB085847 |
| Entrez gene record: |
84447 |
| Pubmed identfication: |
12975321 |
| RefSeq identity: |
NM_032431 |
| Classification: |
Ring finger proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000165607 |