| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Connexin 43 |
| Specificity: |
This antibody reacts specifically with Connexin 43 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Connexin-43 |
| Gene ID: |
2697 |
| Swiss Prot: |
P17302 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Dog, Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A gap junction consists of a cluster of closely packed pairs of transmembrane channels, May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph, Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity), Gap junction protein that acts as a regulator of bladder capacity |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CX43 ODD ODOD SDTY3 |
| Also known as: |
Connexin 43 Polyclonal Antibody |
| Other name: |
Anti-Connexin 43 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Connexin 43 |
| Short name: |
Anti-Connexin 43 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Connexin 43 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4274 |
| Gene: |
GJA1 |
More about : GJA1 |
| Long gene name: |
gap junction protein alpha 1 |
| Synonyms gene: |
ODDD GJAL |
| Synonyms gene name: |
43kDa , 43kDa (connexin 43) gap junction protein, alpha 1, alpha 1, alpha-like gap junction protein, gap junction protein |
| Synonyms name: |
oculodentodigital dysplasia (syndactyly type III) connexin 43 |
| Locus: |
6q22, 31 |
| Discovery year: |
1990-08-03 |
| GenBank acession: |
BC026329 |
| Entrez gene record: |
2697 |
| Pubmed identfication: |
10331943 1646158 |
| RefSeq identity: |
NM_000165 |
| Classification: |
Gap junction proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000015479 |
| Locus Specific Databases: |
Hereditary Hearing Loss Homepage |