| Also known as: |
MUC1 |
| Other names: |
Breast carcinoma-associated antigen DF3, CA 15-3, CD_antigen: CD227Cleaved into the following 2 chains:Mucin-1 subunit alpha, Cancer antigen 15-3, Carcinoma-associated mucin, DF3 antigen, EMA, Episialin, H23 antigen, H23AG, KL-6, Krebs von den Lungen-6, MUC1-NT, MUC1-alpha, MUC1-betaAlternative name(s):MUC1-CT, Medullary cystic kidney disease, Mucin-1, Mucin-1 subunit beta, PEM, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin, autosomal dominant, breast carcinoma-associated antigen DF3, cancer antigen 15-3, carcinoma-associated mucin, cell surface associated, episialin, krebs von den Lungen-6, mucin 1, mucin 1, mucin-1, peanut-reactive urinary mucin, polymorphic epithelial mucin, transmembrane, tumor associated epithelial mucin, tumor-associated epithelial membrane antigen, mucin-1 isoform 2 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
MUC1 |
| Other gene names: |
ADMCKD, ADMCKD1, CA 15-3, CA 15-3, CD227, EMA, EMA, H23AG, KL-6, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1, MUC1-NT, MUC1-alpha, MUC1-beta, MUC1/ZD, PEM, PEM, PEMT, PUM, PUM, PUM, MUC1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
kappa, IgG2a |
| Clone: |
E29 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver, EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack, In immunohistochemical assays, It can act both as an adhesion and an anti-adhesion protein, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The N-terminal alpha subunit and the C-terminal beta subunit, The alpha subunit has cell adhesive properties, The beta subunit contains a C-terminal domain, This particular antibody might cross react with speacies outside of the listed ones, This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex, identified as different glycoforms of EMA, it recognizes proteins in MW range of 265-400kDa, it superbly stains routine formalin/paraffin carcinomas, through phosphorylations and protein-protein interactions, which is involved in cell signaling, In Western blotting |
| Storage and shipping: |
Antibody is stable for 24 months, Temperature variations in the range of 1 to 7 degrees Celsius are tolerable, We recommend NOT to freeze the antibody, Store the antibody at +4C |
| Tested applications:: |
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistology (IH), Immunoprecipitation (IP), Western Blot (WB), ELISA (EIA) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
MUC1/ EMA/ CD227 |
| Short name: |
MUC1/ EMA/ CD227 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MUC1/ EMA/ CD227 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7508 |
| Gene: |
MUC1 |
More about : MUC1 |
| Long gene name: |
cell surface associated , mucin 1 |
| Synonyms gene: |
PUM MCKD1 |
| Synonyms gene name: |
mucin 1, transmembrane medullary cystic kidney disease 1 (autosomal dominant) |
| Synonyms: |
CD227 PEM ADMCKD ADMCKD1 MCKD MCD |
| Locus: |
1q22 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
J05581 |
| Entrez gene record: |
4582 |
| Pubmed identfication: |
1697589 23396133 |
| RefSeq identity: |
NM_002456 |
| Classification: |
Mucins CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000035681 |