| Also known as: |
EMA / MUC1 |
| Other names: |
Breast carcinoma-associated antigen DF3, CA 15-3, CD_antigen: CD227Cleaved into the following 2 chains:Mucin-1 subunit alpha, Cancer antigen 15-3, Carcinoma-associated mucin, DF3 antigen, EMA, Episialin, H23 antigen, H23AG, KL-6, Krebs von den Lungen-6, MUC1-NT, MUC1-alpha, MUC1-betaAlternative name(s):MUC1-CT, Medullary cystic kidney disease, Mucin-1, Mucin-1 subunit beta, PEM, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin, autosomal dominant, breast carcinoma-associated antigen DF3, cancer antigen 15-3, carcinoma-associated mucin, cell surface associated, episialin, krebs von den Lungen-6, mucin 1, mucin 1, mucin-1, peanut-reactive urinary mucin, polymorphic epithelial mucin, transmembrane, tumor associated epithelial mucin, tumor-associated epithelial membrane antigen, mucin-1 isoform 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
EMA |
| Gene name synonims: |
MUC1 |
| Other gene names: |
ADMCKD, ADMCKD1, CA 15-3, CA 15-3, CD227, EMA, EMA, H23AG, KL-6, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1, MUC1-NT, MUC1-alpha, MUC1-beta, MUC1/ZD, PEM, PEM, PEMT, PUM, PUM, PUM, MUC1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
CM1 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
All these MAbs belong to MAb clusters 6 and 7 according to ISOMB TD-4 classification, M2C5, M2C5, M2E104, M2E104 and M3A106: Affinity >, M2F1, M3A106 efficiently recognize underglycosylated and natural MUC1 protein isolated from human milk by affinity chromatography, MAb M4H2 reacts with VNTR20 recombinant unglycosylated fragment of MUC1 protein (and very weakly with monomeric MUC1 peptide), MAbs M2F1, MAbs M4H2, MAbs bind with high efficiency with different epitopes within the VNTR tandem repeat peptide region of MUC1 molecule, No cross-reactivity with egg white avidin, Non cross-reactive with normal serum proteins and human tissues of non-epithelial origin, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, These MAbs do not recognize natural MUC1 protein isolated from human milk by affinity purification on carbohydrate epitope specific MAbs and belong to MAb cluster 1-4 according to ISOMB TD-4 classification, This particular antibody might cross react with speacies outside of the listed ones, which have different conmations and peptide- carbohydrate compositions, with deglycosylated and underglycosylated natural MUC1 (but not with completely glycosylated natural milk MUC1), 1 X 108 all MAbs, VNTR5 and VNTR20 recombinant unglycosylated fragments of MUC1 protein and underglycosylated MUC1 prepared from tumor fluids or as a result of chemical treatment of human milk MUC1 |
| Purification method: |
Protein A Purified |
| Form/Appearance: |
0, pH 7, 1 % sodium azide, 4, PBS |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
Freezing of the antibody is not recommended, Store the antibody at +4 degrees Celsius |
| Tested applications:: |
IHC - Frozen), Immunofluorescence (IF), Immunohistochemistry (IHC - Paraffin |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ CM1] (IgG1) EMA / MUC1 |
| Short name: |
Mouse Monoclonal [clone CM1] (IgG1) EMA / MUC1 Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
sapiens EMA / MUC1 (Antibody to), Mouse monoclonal [clonality CM1] (IgG1) to H |
| Alternative technique: |
antibodies |
| Identity: |
7508 |
| Gene: |
MUC1 |
More about : MUC1 |
| Long gene name: |
cell surface associated , mucin 1 |
| Synonyms gene: |
PUM MCKD1 |
| Synonyms gene name: |
mucin 1, transmembrane medullary cystic kidney disease 1 (autosomal dominant) |
| Synonyms: |
CD227 PEM ADMCKD ADMCKD1 MCKD MCD |
| Locus: |
1q22 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
J05581 |
| Entrez gene record: |
4582 |
| Pubmed identfication: |
1697589 23396133 |
| RefSeq identity: |
NM_002456 |
| Classification: |
Mucins CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000035681 |