| Also known as: |
MUC1 |
| Other names: |
Breast carcinoma-associated antigen DF3, CA 15-3, CD_antigen: CD227Cleaved into the following 2 chains:Mucin-1 subunit alpha, Cancer antigen 15-3, Carcinoma-associated mucin, DF3 antigen, EMA, Episialin, H23 antigen, H23AG, KL-6, Krebs von den Lungen-6, MUC1-NT, MUC1-alpha, MUC1-betaAlternative name(s):MUC1-CT, Medullary cystic kidney disease, Mucin-1, Mucin-1 subunit beta, PEM, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin, autosomal dominant, breast carcinoma-associated antigen DF3, cancer antigen 15-3, carcinoma-associated mucin, cell surface associated, episialin, krebs von den Lungen-6, mucin 1, mucin 1, mucin-1, peanut-reactive urinary mucin, polymorphic epithelial mucin, transmembrane, tumor associated epithelial mucin, tumor-associated epithelial membrane antigen, mucin-1 isoform 2 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
MUC1 |
| Other gene names: |
ADMCKD, ADMCKD1, CA 15-3, CA 15-3, CD227, EMA, EMA, H23AG, KL-6, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1, MUC1-NT, MUC1-alpha, MUC1-beta, MUC1/ZD, PEM, PEM, PEMT, PUM, PUM, PUM, MUC1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
kappa (E29), kappa (GP1, 4) + IgG2a, IgG1 |
| Clone: |
4 + E29, GP1 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver, EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack, In immunohistochemical assays, It can act both as an adhesion and an anti-adhesion protein, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The alpha subunit has cell adhesive properties, The beta subunit contains a C-terminal domain, This particular antibody might cross react with speacies outside of the listed ones, identified as different glycoforms of EMA, it recognizes proteins in MW range of 265-400kDa, it superbly stains routine formalin/paraffin carcinoma tissues, through phosphorylations and protein-protein interactions, which is involved in cell signaling, In Western blotting |
| Storage and shipping: |
Antibody is stable for 24 months, Temperature variations in the range of 1 to 7 degrees Celsius are tolerable, We recommend NOT to freeze the antibody, Store the antibody at +4C |
| Tested applications:: |
Immunofluorescence (IF), Immunohistology (IH), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS) |
| Gene target: |
MUC1/ EMA/ CD227 |
| Short name: |
MUC1/ EMA/ CD227 |
| Alternative name: |
MUC1/ EMA/ CD227 |
| Identity: |
7508 |
| Gene: |
MUC1 |
More about : MUC1 |
| Long gene name: |
cell surface associated , mucin 1 |
| Synonyms gene: |
PUM MCKD1 |
| Synonyms gene name: |
mucin 1, transmembrane medullary cystic kidney disease 1 (autosomal dominant) |
| Synonyms: |
CD227 PEM ADMCKD ADMCKD1 MCKD MCD |
| Locus: |
1q22 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
J05581 |
| Entrez gene record: |
4582 |
| Pubmed identfication: |
1697589 23396133 |
| RefSeq identity: |
NM_002456 |
| Classification: |
Mucins CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000035681 |