| Long name: |
1, 1) Monoclonal Antibody, 3, LGR5/GPR49 (349CT16 |
| Also known as: |
1, 1) Monoclonal Antibody, 3, LGR5/GPR49 (349CT16 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
LGR5/GPR49 |
| Specificity: |
This is a highly specific antibody against LGR5/GPR49 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1, 1, 3, 349CT16 |
| Source: |
This LGR5/GPR49 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 689-719 amino acids from human LGR5/GPR49 |
| Gene ID number: |
8549 |
| Swiss Prot: |
O75473 |
| Tested Applications: |
FCM, WB |
| Recommended dilutions: |
WB(1:2000), FC(1:25) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
In contrast to classical G-protein coupled receptors, Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development, RSPO2, RSPO3 or RSPO4), Upon binding to R-spondins (RSPO1, associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, does not activate heterotrimeric G-proteins to transduce the signal, triggering the canonical Wnt signaling pathway to increase expression of target genes, Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle |
| Purification method: |
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, GPR49, GPR67, GRP49, HG38, LGR5, Leucine-rich repeat-containing G-protein coupled receptor 5, FEX |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
1, 1) Monoclonal, 3, LGR5/GPR49 (349CT16 |
| Short name: |
1, 1) Monoclonal Antibody, 3, LGR5/GPR49 (349CT16 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
1, 1) monoclonal (Antibody to), 3, LGR5/GPR49 (349CT16 |
| Alternative technique: |
antibodies |
| Identity: |
4504 |
| Gene: |
LGR5 |
More about : LGR5 |
| Long gene name: |
leucine rich repeat containing G protein-coupled receptor 5 |
| Synonyms gene: |
GPR67 GPR49 |
| Synonyms gene name: |
G protein-coupled receptor 49 |
| Synonyms: |
HG38 FEX |
| Locus: |
12q21, 1 |
| Discovery year: |
1999-10-22 |
| GenBank acession: |
AF062006 |
| Entrez gene record: |
8549 |
| Pubmed identfication: |
9642114 |
| RefSeq identity: |
NM_003667 |
| Classification: |
Class A orphans , G protein-coupled receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000169543 |