| Long name: |
Biotin Conjugated, KCTD11 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
KCTD11 |
| Specificity: |
This is a highly specific antibody against KCTD11 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human KCTD11 |
| Gene ID number: |
147040 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, Induces apoptosis, Its inactivation might lead to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma, Plays a role as a marker and a regulator of neuronal differentiation, Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB), Up-regulated by a variety of neurogenic signals, epidermal growth factor/EGF and NGFB/nerve growth factor, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B, such as retinoic acid, thus maintaining cerebellar granule cells in undifferentiated state, The KCTD11 gene encodes a protein that has been identified as a suppressor of Hedgehog signaling |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
REN KCASH1 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
KCTD11 Conjugated |
| Short name: |
Conjugated, KCTD11 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, KCTD11 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
21302 |
| Gene: |
KCTD11 |
More about : KCTD11 |
| Long gene name: |
potassium channel tetramerization domain containing 11 |
| Synonyms gene: |
C17orf36 |
| Synonyms gene name: |
chromosome 17 open reading frame 36 potassium channel tetramerisation domain containing 11 |
| Locus: |
17p13, 1 |
| Discovery year: |
2003-06-10 |
| GenBank acession: |
AK056227 |
| Entrez gene record: |
147040 |
| Pubmed identfication: |
12186855 21472142 |
| RefSeq identity: |
NM_001002914 |
| Havana BLAST/BLAT: |
OTTHUMG00000132061 |