| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
KCTD11 |
| Specificity: |
This antibody reacts specifically with KCTD11 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human KCTD11 |
| Gene ID: |
147040 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, Induces apoptosis, Its inactivation might lead to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma, Plays a role as a marker and a regulator of neuronal differentiation, Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB), Up-regulated by a variety of neurogenic signals, epidermal growth factor/EGF and NGFB/nerve growth factor, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B, such as retinoic acid, thus maintaining cerebellar granule cells in undifferentiated state, The KCTD11 gene encodes a protein that has been identified as a suppressor of Hedgehog signaling |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
REN KCASH1 |
| Also known as: |
KCTD11 Polyclonal Antibody |
| Other name: |
Anti-KCTD11 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
KCTD11 |
| Short name: |
Anti-KCTD11 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-KCTD11 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
21302 |
| Gene: |
KCTD11 |
More about : KCTD11 |
| Long gene name: |
potassium channel tetramerization domain containing 11 |
| Synonyms gene: |
C17orf36 |
| Synonyms gene name: |
chromosome 17 open reading frame 36 potassium channel tetramerisation domain containing 11 |
| Locus: |
17p13, 1 |
| Discovery year: |
2003-06-10 |
| GenBank acession: |
AK056227 |
| Entrez gene record: |
147040 |
| Pubmed identfication: |
12186855 21472142 |
| RefSeq identity: |
NM_001002914 |
| Havana BLAST/BLAT: |
OTTHUMG00000132061 |