| Long name: |
Biotin Conjugated, Factor XII heavy chain Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Factor XII heavy chain |
| Specificity: |
This is a highly specific antibody against Factor XII heavy chain |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human Coagulation factor XIIa heavy chain |
| Gene ID number: |
2161 |
| Tested applications: |
IHC-P |
| Recommended dilutions: |
IHC-P(1:100-500) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged, It activates coagulation factors VII and XI, Jul 2008], On activation, Prekallikrein is cleaved by factor XII to form kallikrein, The active factor XIIa participates in the initiation of blood coagulation, The heavy chain contains two fibronectin-type domains, This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain, [provided by RefSeq, a kringle domain and a proline-rich domain, and the generation of bradykinin and angiotensin, fibrinolysis, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain, two epidermal growth factor (EGF)-like domains, whereas the light chain contains only a catalytic domain, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa, This gene encodes coagulation factor XII which circulates in blood as a zymogen |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
Coagulation factor XII, Coagulation factor XIIa heavy chain, Coagulation factor XIIa heavy chain, F12, F12 deficiency, FA12_HUMAN, Factor XII deficiency, Factor XII heavy chain, HAE3, HAEX, HAF, HAF deficiency, Hageman factor, Factor XII |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Factor XII heavy chain Conjugated |
| Short name: |
Conjugated, Factor XII heavy chain Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, Factor XII heavy epitope (Antibody to) |
| Alternative technique: |
antibodies |