| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Factor XII heavy chain |
| Specificity: |
This antibody reacts specifically with Factor XII heavy chain |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Coagulation factor XIIa heavy chain |
| Gene ID: |
2161 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged, It activates coagulation factors VII and XI, Jul 2008], On activation, Prekallikrein is cleaved by factor XII to form kallikrein, The active factor XIIa participates in the initiation of blood coagulation, The heavy chain contains two fibronectin-type domains, This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain, [provided by RefSeq, a kringle domain and a proline-rich domain, and the generation of bradykinin and angiotensin, fibrinolysis, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain, two epidermal growth factor (EGF)-like domains, whereas the light chain contains only a catalytic domain, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa, This gene encodes coagulation factor XII which circulates in blood as a zymogen |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Coagulation factor XII, Coagulation factor XIIa heavy chain, Coagulation factor XIIa heavy chain, F12, F12 deficiency, FA12_HUMAN, Factor XII deficiency, Factor XII heavy chain, HAE3, HAEX, HAF, HAF deficiency, Hageman factor, Factor XII |
| Also known as: |
Factor XII heavy chain Antibody |
| Other name: |
Anti-Factor XII heavy chain |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Factor XII heavy chain |
| Short name: |
Fluor 594, Anti-Factor XII heavy chain |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Factor XII heavy epitope |