| Long name: |
ALEXA FLUOR 488 Conjugated, DDX5 (Tyr593) Polyclonal Antibody |
| Also known as: |
Anti-DDX5 Tyr593 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
DDX5 Tyr593 |
| Specificity: |
This is a highly specific antibody against DDX5 Tyr593 |
| Modification: |
Phosphorylation |
| Modification Site: |
Tyr593 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
577-605/614 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human DDX5 around the phosphorylation site of Tyr593 |
| Gene ID Number: |
1655 |
| Swiss Prot: |
P17844 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts as transcriptional repressor in a promoter-specicic manner, As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms, Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10, Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity, Involved in transcriptional regulation, Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation, The rate of ATP hydrolysis is highly stimulated by single-stranded RNA, Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation, Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR, Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis, its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner, such as HDAC1, the function is independent of the RNA helicase activity, the function probbaly involves association with histone deacetylases, Involved in the alternative regulation of pre-mRNA splicing |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
p68 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the DDX5 (Tyr593) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
DDX5 (Tyr593) |
| Short name: |
DDX5 (Tyr593) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, DDX5 (Tyr593) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2746 |
| Gene: |
DDX5 |
More about : DDX5 |
| Long gene name: |
DEAD-box helicase 5 |
| Synonyms gene: |
HLR1 G17P1 |
| Synonyms gene name: |
68kD) DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase |
| Locus: |
17q23, 3 |
| Discovery year: |
1989-06-30 |
| GenBank acession: |
AF015812 |
| Entrez gene record: |
1655 |
| Pubmed identfication: |
22156369 18698352 |
| RefSeq identity: |
NM_004396 |
| Classification: |
DEAD-box helicases |
| Havana BLAST/BLAT: |
OTTHUMG00000178936 |