| Long name: |
FITC Conjugated, DDX5 (Tyr593) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
DDX5 Tyr593 |
| Specificity: |
This is a highly specific antibody against DDX5 Tyr593 |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr593 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
577-605/614 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human DDX5 around the phosphorylation site of Tyr593 |
| Gene ID number: |
1655 |
| Swiss Prot: |
P17844 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Acts as transcriptional repressor in a promoter-specicic manner, As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms, Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10, Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity, Involved in transcriptional regulation, Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation, The rate of ATP hydrolysis is highly stimulated by single-stranded RNA, Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation, Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR, Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis, its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner, such as HDAC1, the function is independent of the RNA helicase activity, the function probbaly involves association with histone deacetylases, Involved in the alternative regulation of pre-mRNA splicing |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
p68 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
DDX5 (Tyr593) Conjugated |
| Short name: |
FITC Conjugated, DDX5 (Tyr593) Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, DDX5 (Tyr593) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2746 |
| Gene: |
DDX5 |
More about : DDX5 |
| Long gene name: |
DEAD-box helicase 5 |
| Synonyms gene: |
HLR1 G17P1 |
| Synonyms gene name: |
68kD) DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase |
| Locus: |
17q23, 3 |
| Discovery year: |
1989-06-30 |
| GenBank acession: |
AF015812 |
| Entrez gene record: |
1655 |
| Pubmed identfication: |
22156369 18698352 |
| RefSeq identity: |
NM_004396 |
| Classification: |
DEAD-box helicases |
| Havana BLAST/BLAT: |
OTTHUMG00000178936 |