| Long name: |
Cy5, 5 Conjugated, DDX5 (Tyr593) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
DDX5 Tyr593 |
| Specificity: |
This is a highly specific antibody against DDX5 Tyr593 |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr593 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
577-605/614 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human DDX5 around the phosphorylation site of Tyr593 |
| Gene ID number: |
1655 |
| Swiss Prot: |
P17844 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Acts as transcriptional repressor in a promoter-specicic manner, As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms, Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10, Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity, Involved in transcriptional regulation, Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation, The rate of ATP hydrolysis is highly stimulated by single-stranded RNA, Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation, Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR, Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis, its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner, such as HDAC1, the function is independent of the RNA helicase activity, the function probbaly involves association with histone deacetylases, Involved in the alternative regulation of pre-mRNA splicing |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Synonyms: |
p68 |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
DDX5 (Tyr593) Conjugated |
| Short name: |
Conjugated, DDX5 (Tyr593) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, 5 coupled, DDX5 (Tyr593) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2746 |
| Gene: |
DDX5 |
More about : DDX5 |
| Long gene name: |
DEAD-box helicase 5 |
| Synonyms gene: |
HLR1 G17P1 |
| Synonyms gene name: |
68kD) DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase |
| Locus: |
17q23, 3 |
| Discovery year: |
1989-06-30 |
| GenBank acession: |
AF015812 |
| Entrez gene record: |
1655 |
| Pubmed identfication: |
22156369 18698352 |
| RefSeq identity: |
NM_004396 |
| Classification: |
DEAD-box helicases |
| Havana BLAST/BLAT: |
OTTHUMG00000178936 |