LATS1 (Thr1079) Antibody, Cy7 Conjugated

Catalog number:	bs-7913R-Cy7 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	LATS1 (Thr1079) Antibody, Cy7 Conjugated
Quantity:	0.1ml
Related search:	lats antibody antibodies gene tumor suppressor large regulatory

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Long name:	Cy7 Conjugated, LATS1 (Thr1079) Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Cy7
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	LATS1 Thr1079
Specificity:	This sequence will cross react with LATS2 if phosphorylated at Thr1041, This is a highly specific antibody against LATS1 Thr1079
Modification:	Phosphorylation
Modification site:	Thr1079
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	1060-1100/1130
Subcellular location:	Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human LATS1 around the phosphorylation site of Thr1079
Gene ID number:	9113
Swiss Prot:	O95835
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint, Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1, Involved in the control of p53 expression, May also play a role in endocrine function, Negatively regulates G2/M transition by down-regulating CDK1 kinase activity, Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, and cell migration, cell death, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission:	743nm/767nm
Synonyms:	WARTS
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Conjugated:	These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene target:	LATS1 (Thr1079) Conjugated
Short name:	Conjugated, LATS1 (Thr1079) Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Cy7
Alternative name:	cyanine 7 coupled, LATS1 (Thr1079) (Antibody to)
Alternative technique:	antibodies
Identity:	6514
Gene:	LATS1 | More about : LATS1
Long gene name:	large tumor suppressor kinase 1
Synonyms gene name:	Drosophila) homolog 1 LATS, LATS (large tumor suppressor, homolog 1 (Drosophila) , large tumor suppressor
Locus:	6q25, 1
Discovery year:	1999-02-18
GenBank acession:	AF104413
Entrez gene record:	9113
Pubmed identfication:	9988268 15122335
RefSeq identity:	NM_004690
Havana BLAST/BLAT:	OTTHUMG00000016437

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