| Long name: |
LATS1 (Thr1079) Primary Polyclonal Antibody |
| Also known as: |
LATS1 (Thr1079) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
LATS1 Thr1079 |
| Specificity: |
This sequence will cross react with LATS2 if phosphorylated at Thr1041, This is a highly specific antibody against LATS1 Thr1079 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Thr1079 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1060-1100/1130 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human LATS1 around the phosphorylation site of Thr1079 |
| Gene ID number: |
9113 |
| Swiss Prot: |
O95835 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint, Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1, Involved in the control of p53 expression, May also play a role in endocrine function, Negatively regulates G2/M transition by down-regulating CDK1 kinase activity, Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, and cell migration, cell death, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
LATS1, Large tumor suppressor homolog 1, Serine/threonine-protein kinase LATS1, WARTS, WARTS protein kinase, h-warts, wts |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
LATS1 (Thr1079) |
| Short name: |
LATS1 (Thr1079) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
LATS1 (Thr1079) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6514 |
| Gene: |
LATS1 |
More about : LATS1 |
| Long gene name: |
large tumor suppressor kinase 1 |
| Synonyms gene name: |
Drosophila) homolog 1 LATS, LATS (large tumor suppressor, homolog 1 (Drosophila) , large tumor suppressor |
| Synonyms: |
WARTS |
| Locus: |
6q25, 1 |
| Discovery year: |
1999-02-18 |
| GenBank acession: |
AF104413 |
| Entrez gene record: |
9113 |
| Pubmed identfication: |
9988268 15122335 |
| RefSeq identity: |
NM_004690 |
| Havana BLAST/BLAT: |
OTTHUMG00000016437 |