LATS1 (Thr1079) Antibody, ALEXA FLUOR 488

Catalog number:	bs-7913R-A488 Buy Now
Price:	253 €
Supplier:	abbex
Product name:	LATS1 (Thr1079) Antibody, ALEXA FLUOR 488
Quantity:	30 μl
Related search:	lats thr antibody fluor gene tumor suppressor large complex

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Long name:	ALEXA FLUOR 488 Conjugated, LATS1 (Thr1079) Polyclonal Antibody
Also known as:	Anti-LATS1 Thr1079 PAb ALEXA FLUOR 488
Category:	Conjugated Primary Antibodies
Conjugated with:	488, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	LATS1 Thr1079
Specificity:	This is a highly specific antibody against LATS1 Thr1079
Modification:	Phosphorylation
Modification Site:	Thr1079
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	1060-1100/1130
Subcellular location:	Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human LATS1 around the phosphorylation site of Thr1079
Gene ID Number:	9113
Swiss Prot:	O95835
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint, Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1, Involved in the control of p53 expression, May also play a role in endocrine function, Negatively regulates G2/M transition by down-regulating CDK1 kinase activity, Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, and cell migration, cell death, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	499nm/519nm
Synonyms:	WARTS
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the LATS1 (Thr1079) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	Alexa Fluor
Gene target:	LATS1 (Thr1079)
Short name:	LATS1 (Thr1079) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 488
Alternative name:	ALEXA FLUOR 488, LATS1 (Thr1079) (Antibody to)
Alternative technique:	antibodies
Identity:	6514
Gene:	LATS1 | More about : LATS1
Long gene name:	large tumor suppressor kinase 1
Synonyms gene name:	Drosophila) homolog 1 LATS, LATS (large tumor suppressor, homolog 1 (Drosophila) , large tumor suppressor
Locus:	6q25, 1
Discovery year:	1999-02-18
GenBank acession:	AF104413
Entrez gene record:	9113
Pubmed identfication:	9988268 15122335
RefSeq identity:	NM_004690
Havana BLAST/BLAT:	OTTHUMG00000016437

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