| Long name: |
ALEXA FLUOR 647 Conjugated, PNPT1 Polyclonal Antibody |
| Also known as: |
Anti-PNPT1 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PNPT1 |
| Specificity: |
This is a highly specific antibody against PNPT1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
570-620/783 |
| Subcellular location: |
Mitochondrion, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PNPT1 |
| Gene ID Number: |
87178 |
| Swiss Prot: |
Q8TCS8 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Binds to the RNA subunit of ribonuclease P, Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction, Component of the mitochondrial degradosome (mtEXO) complex, In the cytoplasm, MRP RNA and miR-221 microRNA, Mitochondrial intermembrane factor with RNA-processing exoribonulease activity, Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, Plays a role in mitochondrial morphogenesis and respiration, Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs, Regulates the stability of specific mature miRNAs in melanoma cells, Required for correct processing and polyadenylation of mitochondrial mRNAs, degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, into the mitochondrial matrix, like the 5S RNA, preferentially, regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels, resulting in a growth arrest in melanoma cells, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity, specifically and selectively degrades miR-221, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, RNA-binding protein implicated in numerous RNA metabolic processes |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
PNPase OLD35 old-35 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the PNPT1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
PNPT1 |
| Short name: |
PNPT1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, PNPT1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
23166 |
| Gene: |
PNPT1 |
More about : PNPT1 |
| Long gene name: |
polyribonucleotide nucleotidyltransferase 1 |
| Synonyms gene: |
DFNB70 |
| Synonyms gene name: |
autosomal recessive 70 , deafness |
| Synonyms name: |
RNA exonuclease , polynucleotide phosphorylase 3', -5' |
| Locus: |
2p16, 1 |
| Discovery year: |
2003-09-25 |
| GenBank acession: |
BC053660 |
| Entrez gene record: |
87178 |
| Pubmed identfication: |
12419256 |
| RefSeq identity: |
NM_033109 |
| Classification: |
Deafness associated genes |
| Havana BLAST/BLAT: |
OTTHUMG00000129335 |