| Long name: |
Biotin Conjugated, PNPT1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PNPT1 |
| Specificity: |
This is a highly specific antibody against PNPT1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
570-620/783 |
| Subcellular location: |
Mitochondrion, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human PNPT1 |
| Gene ID number: |
87178 |
| Swiss Prot: |
Q8TCS8 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Binds to the RNA subunit of ribonuclease P, Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction, Component of the mitochondrial degradosome (mtEXO) complex, In the cytoplasm, MRP RNA and miR-221 microRNA, Mitochondrial intermembrane factor with RNA-processing exoribonulease activity, Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, Plays a role in mitochondrial morphogenesis and respiration, Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs, Regulates the stability of specific mature miRNAs in melanoma cells, Required for correct processing and polyadenylation of mitochondrial mRNAs, degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, into the mitochondrial matrix, like the 5S RNA, preferentially, regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels, resulting in a growth arrest in melanoma cells, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity, specifically and selectively degrades miR-221, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, RNA-binding protein implicated in numerous RNA metabolic processes |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
PNPase OLD35 old-35 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PNPT1 Conjugated |
| Short name: |
Conjugated, PNPT1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, PNPT1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
23166 |
| Gene: |
PNPT1 |
More about : PNPT1 |
| Long gene name: |
polyribonucleotide nucleotidyltransferase 1 |
| Synonyms gene: |
DFNB70 |
| Synonyms gene name: |
autosomal recessive 70 , deafness |
| Synonyms name: |
RNA exonuclease , polynucleotide phosphorylase 3', -5' |
| Locus: |
2p16, 1 |
| Discovery year: |
2003-09-25 |
| GenBank acession: |
BC053660 |
| Entrez gene record: |
87178 |
| Pubmed identfication: |
12419256 |
| RefSeq identity: |
NM_033109 |
| Classification: |
Deafness associated genes |
| Havana BLAST/BLAT: |
OTTHUMG00000129335 |