| Long name: |
CstF-64 Primary Polyclonal Antibody |
| Also known as: |
CstF-64 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CstF-64 |
| Specificity: |
This is a highly specific antibody against CstF-64 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CSTF2T/CstF-64 |
| Gene ID number: |
23283 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
CstF-64 contains an RNA binding domain and is responsible for the RNA binding activity of CstF, CstF-64 is expressed in all somatic cells and in pre- and postmeiotic, However, The first step, The gene encoding CstF-64 (designated CSTF2) maps to the X chromosome, The increase in CstF-64 concentration during B cell activation switches IgM heavy chain mRNA expression from membrane-bound to secreted forms, a heterotrimer that is composed of three distinct subunits, a large variant of CstF-64, and promotes the germ cell pattern of polyadenylation, but not meiotic, called t CstF-64, endonucleolytic cleavage of polyadenylation substrates, germ cells, is abundantly expressed in meiotic and postmeiotic cells in the testis and to a lesser extent in the brain, requires CstF (cleavage stimulation factor), suggesting that CstF-64 plays a key role in regulating IgM heavy chain expression during B cell differentiation, whereas t CstF-64 is encoded by an autosomal gene, Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CSTF 64 kDa subunit, CSTFT_HUMAN, Cleavage stimulation factor 64 kDa subunit, KIAA0689, TauCstF64, tau variant, tau variant, tau variant, CF1 64 kDa subunit |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CstF-64 |
| Short name: |
CstF-64 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CstF-64 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2484 |
| Gene: |
CSTF2 |
More about : CSTF2 |
| Long gene name: |
cleavage stimulation factor subunit 2 |
| Synonyms gene name: |
3', 3', 64kD cleavage stimulation factor, cleavage stimulation factor, pre-RNA, pre-RNA, subunit 2, subunit 2 |
| Synonyms: |
CstF-64 |
| Locus: |
Xq22, 1 |
| Discovery year: |
1994-12-12 |
| GenBank acession: |
BC017712 |
| Entrez gene record: |
1478 |
| Pubmed identfication: |
1741396 |
| RefSeq identity: |
NM_001325 |
| Classification: |
RNA binding motif containing |
| Havana BLAST/BLAT: |
OTTHUMG00000022709 |
| Locus Specific Databases: |
Mental Retardation database |