| Long name: |
ALEXA FLUOR 647 Conjugated, YES1 (Tyr426) Polyclonal Antibody |
| Also known as: |
Anti-YES1 Tyr426 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
YES1 Tyr426 |
| Specificity: |
This is a highly specific antibody against YES1 Tyr426 |
| Modification: |
Phosphorylation |
| Modification Site: |
Tyr426 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
420-430/543 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human YES1 around the phosphorylation site of Tyr426 |
| Gene ID Number: |
7525 |
| Swiss Prot: |
P07947 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Also involved in G2/M progression and cytokinesis, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, PDGFR, Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration, Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts, Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase, Stimulation by receptor tyrosine kinases (RTKs) including EGRF, Upon EGFR activation, Upon T-cell stimulation by CXCL12, and activation and phosphorylation of downstream substrates, and differentiation, apoptosis, cell-cell adhesion, cytoskeleton remodeling, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly, Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
Yes c-yes HsT441 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the YES1 (Tyr426) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
YES1 (Tyr426) |
| Short name: |
YES1 (Tyr426) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, YES1 (Tyr426) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12841 |
| Gene: |
YES1 |
More about : YES1 |
| Long gene name: |
Src family tyrosine kinase , YES proto-oncogene 1 |
| Synonyms gene name: |
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 |
| Locus: |
18p11, 32 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M15990 |
| Entrez gene record: |
7525 |
| Pubmed identfication: |
2983418 |
| RefSeq identity: |
NM_005433 |
| Classification: |
SH2 domain containing Src family tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000131472 |