| Long name: |
YES1 (Tyr426) Primary Polyclonal Antibody |
| Also known as: |
YES1 (Tyr426) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
YES1 Tyr426 |
| Specificity: |
Due to the highly conserved nature of this protein, Src(Tyr418), and Lyn (Tyr397) if phosphorylated at this site due to homology, this antibody will react with the related proteins LCK(Tyr394), This is a highly specific antibody against YES1 Tyr426 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Tyr426 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
420-430/543 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human YES1 around the phosphorylation site of Tyr426 |
| Gene ID number: |
7525 |
| Swiss Prot: |
P07947 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also involved in G2/M progression and cytokinesis, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, PDGFR, Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration, Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts, Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase, Stimulation by receptor tyrosine kinases (RTKs) including EGRF, Upon EGFR activation, Upon T-cell stimulation by CXCL12, and activation and phosphorylation of downstream substrates, and differentiation, apoptosis, cell-cell adhesion, cytoskeleton remodeling, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly, Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
HsT441, P61-YES, Proto-oncogene c-Yes, Tyrosine-protein kinase Yes, YES1, c-yes, Yes |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
YES1 (Tyr426) |
| Short name: |
YES1 (Tyr426) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
YES1 (Tyr426) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12841 |
| Gene: |
YES1 |
More about : YES1 |
| Long gene name: |
Src family tyrosine kinase , YES proto-oncogene 1 |
| Synonyms gene name: |
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 |
| Synonyms: |
Yes c-yes HsT441 |
| Locus: |
18p11, 32 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M15990 |
| Entrez gene record: |
7525 |
| Pubmed identfication: |
2983418 |
| RefSeq identity: |
NM_005433 |
| Classification: |
SH2 domain containing Src family tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000131472 |