| Long name: |
50) Monoclonal Antibody, 7, YES1 (1612CT505 |
| Also known as: |
50) Monoclonal Antibody, 7, YES1 (1612CT505 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
YES1 |
| Specificity: |
This is a highly specific antibody against YES1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1612CT505, 7, 50 |
| Source: |
This YES1 antibody is generated from a mouse immunized with a recombinant protein of human YES1 |
| Gene ID number: |
7525 |
| Swiss Prot: |
P07947 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:4000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also involved in G2/M progression and cytokinesis, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, PDGFR, Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration, Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts, Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase, Stimulation by receptor tyrosine kinases (RTKs) including EGRF, Upon EGFR activation, Upon T-cell stimulation by CXCL12, and activation and phosphorylation of downstream substrates, and differentiation, apoptosis, cell-cell adhesion, cytoskeleton remodeling, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly, Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
HsT441, P61-YES, Proto-oncogene c-Yes, Tyrosine-protein kinase Yes, YES1, c-yes, Yes |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
50) Monoclonal, 7, YES1 (1612CT505 |
| Short name: |
50) Monoclonal Antibody, 7, YES1 (1612CT505 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
50) monoclonal (Antibody to), 7, YES1 (1612CT505 |
| Alternative technique: |
antibodies |
| Identity: |
12841 |
| Gene: |
YES1 |
More about : YES1 |
| Long gene name: |
Src family tyrosine kinase , YES proto-oncogene 1 |
| Synonyms gene name: |
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 |
| Synonyms: |
Yes c-yes HsT441 |
| Locus: |
18p11, 32 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M15990 |
| Entrez gene record: |
7525 |
| Pubmed identfication: |
2983418 |
| RefSeq identity: |
NM_005433 |
| Classification: |
SH2 domain containing Src family tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000131472 |