| Long name: |
Cy3 Conjugated, IGF1R (Tyr980) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
cy3 conjugation kit |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
IGF1R Tyr980 |
| Specificity: |
This is a highly specific antibody against IGF1R Tyr980 |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr980 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
960-1000/1367 |
| Subcellular location: |
Cell membrane |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human IGF1R around the phosphorylation site of Tyr980 |
| Gene ID number: |
3480 |
| Swiss Prot: |
P08069 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
IGF2 and insulin, In contrast, PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, binds IGF1, both bind IGF1 and have a low affinity for insulin, with low affinity by IGF2 and not significantly activated by insulin, When present in a hybrid receptor with INSR |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
512, 550nm/570, 615nm |
| Synonyms: |
JTK13 CD221 IGFIR MGC18216 IGFR |
| Properties: |
1 of the IGF1R (Tyr980) Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
IGF1R (Tyr980) Conjugated |
| Short name: |
Conjugated, IGF1R (Tyr980) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy3 |
| Alternative name: |
cyanine 3 coupled, insulin-like growth factor 1 receptor (Tyr980) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD221 and IGFIR and IGFR and JTK13, Cell surfaces, IGF1R and IDBG-31432 and ENSG00000140443 and 3480, IGF1R and IDBG-628659 and ENSBTAG00000021527 and 281848, Igf1r and IDBG-192339 and ENSMUSG00000005533 and 16001, this GO :0001965 and G-protein alpha-subunit binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0005010 and insulin-like growth factor-activated receptor activity and molecular function this GO :0005158 and insulin receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005520 and insulin-like growth factor binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005901 and caveola and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006955 and immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007409 and axonogenesis and biological process this GO :0007420 and brain development and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008544 and epidermis development and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0010656 and negative regulation of muscle cell apoptotic process and biological process this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016772 and transferase activity, this GO :0001965 : G-protein alpha-subunit binding, this GO :0001965 : G-protein alpha-subunit binding and also this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0005010 : insulin-like growth factor-activated receptor activity and also this GO :0005158 : insulin receptor binding and also this GO :0005515 : protein binding and also this GO :0005520 : insulin-like growth factor binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0005010 : insulin-like growth factor-activated receptor activity, this GO :0005158 : insulin receptor binding, this GO :0005515 : protein binding, this GO :0005520 : insulin-like growth factor binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0031994 : insulin-like growth factor I binding, this GO :0042802 : identical protein binding, this GO :0043548 : phosphatidylinositol 3-kinase binding, this GO :0043559 : insulin binding, this GO :0043560 : insulin receptor substrate binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0031994 : insulin-like growth factor I binding and also this GO :0042802 : identical protein binding and also this GO :0043548 : phosphatidylinositol 3-kinase binding and also this GO :0043559 : insulin binding and also this GO :0043560 : insulin receptor substrate binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0030010 and establishment of cell polarity and biological process this GO :0030238 and male sex determination and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030879 and mammary gland development and biological process this GO :0031017 and exocrine pancreas development and biological process this GO :0031175 and neuron projection development and biological process this GO :0031994 and insulin-like growth factor I binding and molecular function this GO :0032467 and positive regulation of cytokinesis and biological process this GO :0033197 and response to vitamin E and biological process this GO :0038083 and peptidyl-tyrosine autophosphorylation and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043005 and neuron projection and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043235 and receptor complex and cellular component this GO :0043409 and negative regulation of MAPK cascade and biological process this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0043548 and phosphatidylinositol 3-kinase binding and molecular function this GO :0043559 and insulin binding and molecular function this GO :0043560 and insulin receptor substrate binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045740 and positive regulation of DNA replication and biological process this GO :0045840 and positive regulation of mitosis and biological process this GO :0046328 and regulation of JNK cascade and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048009 and insulin-like growth factor receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0051054 and positive regulation of DNA metabolic process and biological process this GO :0051262 and protein tetramerization and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051389 and inactivation of MAPKK activity and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0051898 and negative regulation of protein kinase B signaling and biological process this GO :0060740 and prostate gland epithelium morphogenesis and biological process this GO :0090031 and positive regulation of steroid hormone biosynthetic process and biological process, insulin-like growth factor 1 receptor |
| Identity: |
5465 |
| Gene: |
IGF1R |
More about : IGF1R |
| Long gene name: |
insulin like growth factor 1 receptor |
| Synonyms gene name: |
insulin-like growth factor 1 receptor |
| Locus: |
15q26, 3 |
| Discovery year: |
1988-07-07 |
| GenBank acession: |
M69229 |
| Entrez gene record: |
3480 |
| Pubmed identfication: |
1316909 |
| RefSeq identity: |
NM_000875 |
| Classification: |
CD molecules Fibronectin type III domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000149851 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database LRG_1055 |