| Long name: |
Cy3 Conjugated, Jak3 (Tyr980 + Tyr981) Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
cy3 conjugation kit |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Jak3 Tyr980 + Tyr981 |
| Specificity: |
These phosphorylation sites are homologous to Tyr976 + Tyr977 in Mouse and Rat, This is a highly specific antibody against Jak3 Tyr980 + Tyr981 |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr980 + Tyr981 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
971-990/1124 |
| Subcellular location: |
Cell membrane, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human Jak3 around the phosphorylation site of Tyr980/981 |
| Gene ID number: |
3718 |
| Swiss Prot: |
P52333 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Following ligand binding to cell surface receptors, For example, IL15R and IL21R, IL4R, IL7R, IL9R, In the cytoplasm, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain, Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development, Once activated, Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription, STAT5A AND STAT5B are recruited, Subsequently, Then, creating docking sites for STATs proteins, development, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion, or differentiation, phosphorylated and activated by JAK1 and JAK3, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, phosphorylates the STATs proteins once they are recruited to the receptor, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, upon IL2R activation by IL2, Non-receptor tyrosine kinase involved in various processes such as cell growth |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
512, 550nm/570, 615nm |
| Synonyms: |
JAK-3, JAK3, JAK3_HUMAN, Janus kinase 3, L-JAK, LJAK, Leukocyte janus kinase, Tyrosine-protein kinase JAK3, JAKL |
| Properties: |
1 of the Jak3 (Tyr980 + Tyr981) Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Jak3 (Tyr980 + Tyr981) Conjugated |
| Short name: |
Conjugated, Jak3 (Tyr980 + Tyr981) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy3 |
| Alternative name: |
cyanine 3 coupled, Janus kinase 3 (Tyr980 and Tyr981) (Antibody to) |
| Alternative technique: |
antibodies |