Jak3 (Tyr980 + Tyr981) Antibody

Catalog number:	bs-3208R Buy Now
Price:	265 €
Supplier:	MBS Polyclonals
Product name:	Jak3 (Tyr980 + Tyr981) Antibody
Quantity:	0.06 ml
Related search:	tyr jak antibody ilr antibodies kinase phosphorylation janus gamma

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Long name:	Jak3 (Tyr980 + Tyr981) Antibody
Also known as:	Jak3 (Tyr980 + Tyr981) Antibody
Category:	Primary Antibodies
Conjugation:	Unconjugated
Target Antigen:	Jak3 Tyr980 + Tyr981
Specificity:	These phosphorylation sites are homologous to Tyr976 + Tyr977 in Mouse and Rat, This is a highly specific antibody against Jak3 Tyr980 + Tyr981
Modification(s):	Phosphorylation
Modification site(s):	Tyr980 + Tyr981
Clonality:	Polyclonal antibody
Clone number:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	971-990/1124
Subcellular location:	Cell membrane, Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human Jak3 around the phosphorylation site of Tyr980/981
Gene ID number:	3718
Swiss Prot:	P52333
Tested Applications:	IF(IHC-P), IHC-P, WB
Recommended dilutions:	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity:	Mouse, Rat, Human
Cross reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen:	Following ligand binding to cell surface receptors, For example, IL15R and IL21R, IL4R, IL7R, IL9R, In the cytoplasm, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain, Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development, Once activated, Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription, STAT5A AND STAT5B are recruited, Subsequently, Then, creating docking sites for STATs proteins, development, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion, or differentiation, phosphorylated and activated by JAK1 and JAK3, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, phosphorylates the STATs proteins once they are recruited to the receptor, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, upon IL2R activation by IL2, Non-receptor tyrosine kinase involved in various processes such as cell growth
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names:	JAK-3, JAK3, JAK3_HUMAN, Janus kinase 3, L-JAK, LJAK, Leukocyte janus kinase, Tyrosine-protein kinase JAK3, JAKL
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target:	Jak3 (Tyr980 + Tyr981)
Short name:	Jak3 (Tyr980 + Tyr981) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Alternative name:	Janus kinase 3 (Tyr980 and Tyr981) (Antibody to)
Alternative technique:	antibodies

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