| Long name: |
Cy7 Conjugated, MUC4 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy7 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MUC4 |
| Specificity: |
This is a highly specific antibody against MUC4 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
1240-1290/2169 |
| Subcellular location: |
Cell membrane, Secreted |
| Source: |
KLH conjugated synthetic peptide derived from human Mucin-4 alpha chain |
| Gene ID number: |
4585 |
| Swiss Prot: |
Q99102 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation, Has anti-adhesive properties, In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor, Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2, Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2, The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248', The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, The interaction with ERBB2 leads to enhanced expression of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation, May play a role in tumor progression |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
743nm/767nm |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths |
| Gene target: |
MUC4 Conjugated |
| Short name: |
Conjugated, MUC4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy7 |
| Alternative name: |
cellular surface associated (Antibody to), cyanine 7 coupled, mucin 4 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ASGP and HSA276359 and MUC-4, Extracellular, MUC4 and IDBG-633795 and ENSBTAG00000014721 and, MUC4 and IDBG-70699 and ENSG00000145113 and 4585, Muc4 and IDBG-250337 and ENSMUSG00000079620 and 140474, cell surface associated, extracellular matrix constituent, lubricant activity, lubricant activity, lubricant activity and molecular function this GO :0030277 and maintenance of gastrointestinal epithelium and biological process this GO :0043687 and post-translational protein modification and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0002244 and hematopoietic progenitor cell differentiation and biological process this GO :0005176 and ErbB-2 class receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005578 and proteinaceous extracellular matrix and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005796 and this GO lgi lumen and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007160 and cell-matrix adhesion and biological process this GO :0016020 and membrane and cellular component this GO :0016266 and O-glycan processing and biological process this GO :0030197 and extracellular matrix constituent, this GO :0005176 : ErbB-2 class receptor binding, this GO :0005176 : ErbB-2 class receptor binding and also this GO :0005515 : protein binding and also this GO :0030197 : extracellular matrix constituent, this GO :0005515 : protein binding, this GO :0030197 : extracellular matrix constituent, mucin 4 |
| Identity: |
7514 |
| Gene: |
MUC4 |
More about : MUC4 |
| Long gene name: |
cell surface associated , mucin 4 |
| Synonyms gene name: |
mucin 4, tracheobronchial |
| Locus: |
3q29 |
| Discovery year: |
1991-05-22 |
| GenBank acession: |
AJ276359 |
| Entrez gene record: |
4585 |
| Pubmed identfication: |
1673336 |
| RefSeq identity: |
NM_018406 |
| Classification: |
Mucins |
| Havana BLAST/BLAT: |
OTTHUMG00000151827 |