| Long name: |
ALEXA FLUOR 647 Conjugated, MUC4 Polyclonal Antibody |
| Also known as: |
Anti-MUC4 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MUC4 |
| Specificity: |
This is a highly specific antibody against MUC4 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1240-1290/2169 |
| Subcellular location: |
Cell membrane, Secreted |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Mucin-4 alpha chain |
| Gene ID Number: |
4585 |
| Swiss Prot: |
Q99102 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation, Has anti-adhesive properties, In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor, Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2, Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2, The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248', The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, The interaction with ERBB2 leads to enhanced expression of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation, May play a role in tumor progression |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the MUC4 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
MUC4 |
| Short name: |
MUC4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, cellular surface associated (Antibody to), mucin 4 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ASGP and HSA276359 and MUC-4, Extracellular, MUC4 and IDBG-633795 and ENSBTAG00000014721 and, MUC4 and IDBG-70699 and ENSG00000145113 and 4585, Muc4 and IDBG-250337 and ENSMUSG00000079620 and 140474, cell surface associated, extracellular matrix constituent, lubricant activity, lubricant activity, lubricant activity and molecular function this GO :0030277 and maintenance of gastrointestinal epithelium and biological process this GO :0043687 and post-translational protein modification and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0002244 and hematopoietic progenitor cell differentiation and biological process this GO :0005176 and ErbB-2 class receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005578 and proteinaceous extracellular matrix and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005796 and this GO lgi lumen and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007160 and cell-matrix adhesion and biological process this GO :0016020 and membrane and cellular component this GO :0016266 and O-glycan processing and biological process this GO :0030197 and extracellular matrix constituent, this GO :0005176 : ErbB-2 class receptor binding, this GO :0005176 : ErbB-2 class receptor binding and also this GO :0005515 : protein binding and also this GO :0030197 : extracellular matrix constituent, this GO :0005515 : protein binding, this GO :0030197 : extracellular matrix constituent, mucin 4 |
| Identity: |
7514 |
| Gene: |
MUC4 |
More about : MUC4 |
| Long gene name: |
cell surface associated , mucin 4 |
| Synonyms gene name: |
mucin 4, tracheobronchial |
| Locus: |
3q29 |
| Discovery year: |
1991-05-22 |
| GenBank acession: |
AJ276359 |
| Entrez gene record: |
4585 |
| Pubmed identfication: |
1673336 |
| RefSeq identity: |
NM_018406 |
| Classification: |
Mucins |
| Havana BLAST/BLAT: |
OTTHUMG00000151827 |