| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Mucin-4 alpha chain / MUC4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the MUC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This MUC4 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q99102 |
| Purity: |
Antigen affinity |
| Description: |
Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation, Has anti-adhesive properties, In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor, Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2, Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2, The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248', The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, The interaction with ERBB2 leads to enhanced expression of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation, May play a role in tumor progression |
| Immunogen: |
This MUC4 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 529-560 amino acids from the N-terminal region of human Mucin-4 alpha chain |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the MUC4 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Mucin-4 alpha chain / MUC4 |
| Short name: |
Mucin-4 alpha chain / MUC4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
cellular surface associated (Antibody to), Mucin-4 a epitope / mucin 4 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ASGP and HSA276359 and MUC-4, Extracellular, MUC4 and IDBG-633795 and ENSBTAG00000014721 and, MUC4 and IDBG-70699 and ENSG00000145113 and 4585, Muc4 and IDBG-250337 and ENSMUSG00000079620 and 140474, cell surface associated, extracellular matrix constituent, lubricant activity, lubricant activity, lubricant activity and molecular function this GO :0030277 and maintenance of gastrointestinal epithelium and biological process this GO :0043687 and post-translational protein modification and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0002244 and hematopoietic progenitor cell differentiation and biological process this GO :0005176 and ErbB-2 class receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005578 and proteinaceous extracellular matrix and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005796 and this GO lgi lumen and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007160 and cell-matrix adhesion and biological process this GO :0016020 and membrane and cellular component this GO :0016266 and O-glycan processing and biological process this GO :0030197 and extracellular matrix constituent, this GO :0005176 : ErbB-2 class receptor binding, this GO :0005176 : ErbB-2 class receptor binding and also this GO :0005515 : protein binding and also this GO :0030197 : extracellular matrix constituent, this GO :0005515 : protein binding, this GO :0030197 : extracellular matrix constituent, mucin 4 |
| Identity: |
7514 |
| Gene: |
MUC4 |
More about : MUC4 |
| Long gene name: |
cell surface associated , mucin 4 |
| Synonyms gene name: |
mucin 4, tracheobronchial |
| Locus: |
3q29 |
| Discovery year: |
1991-05-22 |
| GenBank acession: |
AJ276359 |
| Entrez gene record: |
4585 |
| Pubmed identfication: |
1673336 |
| RefSeq identity: |
NM_018406 |
| Classification: |
Mucins |
| Havana BLAST/BLAT: |
OTTHUMG00000151827 |