| Long name: |
Cy5, 5 Conjugated, CARM1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CARM1 |
| Specificity: |
This is a highly specific antibody against CARM1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
430-480/608 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human CARM1 |
| Gene ID number: |
10498 |
| Swiss Prot: |
Q86X55 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Acts as coactivator for PPARG, Also methylates arginine residues in RNA-binding proteins PABPC1, Also seems to be involved in p53/TP53 transcriptional activation, During monocyte inflammatory stimulation, During myogenic transcriptional activation, During nuclear hormone receptor activation and TCF7L2/TCF4 activation, ELAVL1 and ELAV4, Methylates EP300/P300, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription, Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors, Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, acts together with EP300/P300 as a coactivator for NF-kappa-B, acts together with NCOA3/ACTR as a coactivator for MEF2C, and at 'Arg-580' and 'Arg-604' in the KIX domain, and mRNA stability, both at 'Arg-2142', forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling, methylates histone H3 at 'Arg-17' (H3R17me), pre-mRNA splicing, promotes adipocyte differentiation and the accumulation of brown fat tissue, transcription regulation, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs, which may loosen its interaction with NCOA2/GRIP1, Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Synonyms: |
PRMT4 |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
CARM1 Conjugated |
| Short name: |
Conjugated, CARM1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, 5 coupled, CARM1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
23393 |
| Gene: |
CARM1 |
More about : CARM1 |
| Long gene name: |
coactivator associated arginine methyltransferase 1 |
| Locus: |
19p13, 2 |
| Discovery year: |
2003-11-14 |
| GenBank acession: |
AF055027 |
| Entrez gene record: |
10498 |
| Pubmed identfication: |
10381882 11724789 |
| RefSeq identity: |
NM_199141 |
| Classification: |
Protein arginine methyltransferases |
| Havana BLAST/BLAT: |
OTTHUMG00000180699 |