CHK2 (Thr68) Antibody, ALEXA FLUOR 594

Catalog number:	bs-3721R-A594 Buy Now
Price:	332 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	CHK2 (Thr68) Antibody, ALEXA FLUOR 594
Quantity:	100ul
Related search:	phosphorylation thr gene cell cycle checkpoint synonyms genes

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Long name:	ALEXA FLUOR 594 Conjugated, CHK2 (Thr68) Polyclonal Antibody
Also known as:	Anti-CHK2 Thr68 PAb ALEXA FLUOR 594
Category:	Conjugated Primary Antibodies
Conjugated with:	594, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	CHK2 Thr68
Specificity:	This is a highly specific antibody against CHK2 Thr68
Modification:	Phosphorylation
Modification Site:	Thr68
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	50-90/543
Subcellular location:	Nucleus
Source:	KLH conjugated synthetic phosphopeptide derived from human CHK2 around the phosphorylation site of Thr68
Gene ID Number:	11200
Swiss Prot:	O96017
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1, Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1, CDC25B and CDC25C, Following activation, Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression, Its absence may be a cause of the chromosomal instability observed in some cancer cells, MDM4 and PML, May also negatively regulate cell cycle progression during unperturbed cell cycles, May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest, Phosphorylation of MDM4 may also reduce degradation of p53/TP53, Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, Regulates DNA repair through phosphorylation of BRCA2, Regulates apoptosis through the phosphorylation of p53/TP53, Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, Tumor suppressor, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination, inhibiting their activity, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1, leading to accumulation of active p53/TP53, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T], Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	590nm/617nm
Synonyms:	CDS1 CHK2 HuCds1 PP1425 bA444G7
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	594, ALEXA FLUOR®, Alexa Fluor
Conjugated:	Alexa conjugate 1
Gene target:	CHK2 (Thr68)
Short name:	CHK2 (Thr68) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 594
Alternative name:	ALEXA FLUOR 594, CHK2 (Thr68) (Antibody to)
Alternative technique:	antibodies
Identity:	16627
Gene:	CHEK2 | More about : CHEK2
Long gene name:	checkpoint kinase 2
Synonyms gene:	RAD53
Synonyms gene name:	CHK2 (checkpoint, S, pombe) , pombe) homolog CHK2 checkpoint homolog (S
Locus:	22q12, 1
Discovery year:	2001-09-19
GenBank acession:	AF086904
Entrez gene record:	11200
Pubmed identfication:	9836640 10097108
RefSeq identity:	NM_001005735
Havana BLAST/BLAT:	OTTHUMG00000151023
Locus Specific Databases:	LRG_302

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