CHK2 (ser19) Antibody, ALEXA FLUOR 594

Catalog number:	bs-4000R-A594 Buy Now
Price:	332 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	CHK2 (ser19) Antibody, ALEXA FLUOR 594
Quantity:	100ul
Related search:	ser alexa gene thr kinase checkpoint synonyms activation

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Long name:	ALEXA FLUOR 594 Conjugated, CHK2 (ser19) Polyclonal Antibody
Also known as:	Anti-CHK2 ser19 PAb ALEXA FLUOR 594
Category:	Conjugated Primary Antibodies
Conjugated with:	594, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	CHK2 ser19
Specificity:	This is a highly specific antibody against CHK2 ser19
Modification:	Phosphorylation
Modification Site:	ser19
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Source:	KLH conjugated synthetic phosphopeptide derived from human CHK2 around the phosphorylation site of ser19
Gene ID Number:	11200
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases, Indeed, Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block, Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif), The SQ/TQ cluster domain, The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, These are known to be preferred sites for phosphorylation by ATM/ATR kinases, This kinase may have a role in meiosis as well, Thr26, Thr68 and other sites in this region become phosphorylated by ATM/ATR, UV irradiation or hydroxyurea treatment, after DNA damage by ionizing radiation (IR), and may also participate in transduction of the DNA damage and replicational stress signals, preventing the entry into mitosis, seems to have a regulatory function, therefore, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain, Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	590nm/617nm
Synonyms:	CDS1 CHK2 HuCds1 PP1425 bA444G7
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	594, ALEXA FLUOR®, Alexa Fluor
Conjugated:	Alexa conjugate 1
Gene target:	CHK2 (ser19)
Short name:	CHK2 (ser19) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 594
Alternative name:	ALEXA FLUOR 594, CHK2 (ser19) (Antibody to)
Alternative technique:	antibodies
Identity:	16627
Gene:	CHEK2 | More about : CHEK2
Long gene name:	checkpoint kinase 2
Synonyms gene:	RAD53
Synonyms gene name:	CHK2 (checkpoint, S, pombe) , pombe) homolog CHK2 checkpoint homolog (S
Locus:	22q12, 1
Discovery year:	2001-09-19
GenBank acession:	AF086904
Entrez gene record:	11200
Pubmed identfication:	9836640 10097108
RefSeq identity:	NM_001005735
Havana BLAST/BLAT:	OTTHUMG00000151023
Locus Specific Databases:	LRG_302

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