CHK2 (Thr68) Antibody, FITC Conjugated

Catalog number:	bs-3721R-FITC Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	CHK2 (Thr68) Antibody, FITC Conjugated
Quantity:	0.1ml
Related search:	antibody phosphorylation antibodies thr gene cell cycle checkpoint fluorescent site

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Long name:	FITC Conjugated, CHK2 (Thr68) Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Anti-FITC Antibody
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	CHK2 Thr68
Specificity:	This is a highly specific antibody against CHK2 Thr68
Modification:	Phosphorylation
Modification site:	Thr68
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	50-90/543
Subcellular location:	Nucleus
Source:	KLH conjugated synthetic phosphopeptide derived from human CHK2 around the phosphorylation site of Thr68
Gene ID number:	11200
Swiss Prot:	O96017
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1, Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1, CDC25B and CDC25C, Following activation, Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression, Its absence may be a cause of the chromosomal instability observed in some cancer cells, MDM4 and PML, May also negatively regulate cell cycle progression during unperturbed cell cycles, May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest, Phosphorylation of MDM4 may also reduce degradation of p53/TP53, Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, Regulates DNA repair through phosphorylation of BRCA2, Regulates apoptosis through the phosphorylation of p53/TP53, Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, Tumor suppressor, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination, inhibiting their activity, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1, leading to accumulation of active p53/TP53, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T], Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission:	494nm/518nm
Synonyms:	CDS1 CHK2 HuCds1 PP1425 bA444G7
Properties:	Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	CHK2 (Thr68) Conjugated
Short name:	FITC Conjugated, CHK2 (Thr68) Antibody
Technique:	Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	FITC
Alternative name:	fluorecein coupled, CHK2 (Thr68) (Antibody to)
Alternative technique:	antibodies
Identity:	16627
Gene:	CHEK2 | More about : CHEK2
Long gene name:	checkpoint kinase 2
Synonyms gene:	RAD53
Synonyms gene name:	CHK2 (checkpoint, S, pombe) , pombe) homolog CHK2 checkpoint homolog (S
Locus:	22q12, 1
Discovery year:	2001-09-19
GenBank acession:	AF086904
Entrez gene record:	11200
Pubmed identfication:	9836640 10097108
RefSeq identity:	NM_001005735
Havana BLAST/BLAT:	OTTHUMG00000151023
Locus Specific Databases:	LRG_302

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