p95 NBS1 (Ser343) Antibody, Cy5 Conjugated

Catalog number:	bs-3718R-Cy5 Buy Now
Price:	393 €
Supplier:	MBS Polyclonals
Product name:	p95 NBS1 (Ser343) Antibody, Cy5 Conjugated
Quantity:	100ug
Related search:	antibody dna complex nbn damage proximity

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Long name:	Cy5 Conjugated, p95 NBS1 (Ser343) Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	5, Cy5
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	p95 NBS1 Ser343
Specificity:	This is a highly specific antibody against p95 NBS1 Ser343
Modification:	Phosphorylation
Modification site:	Ser343
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	320-370/754
Subcellular location:	Nucleus
Source:	KLH conjugated synthetic phosphopeptide derived from human NBS1 around the phosphorylation site of Ser343
Gene ID number:	4683
Swiss Prot:	O60934
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	ATR, DNA recombination, Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex, Forms a complex with RBBP8 to link DNA double-strand break sensing to resection, It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX, NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation, NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints, NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, RAD50 may be required to bind DNA ends and hold them in close proximity, The complex is involved in double-strand break (DSB) repair, The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, The roles of NBS1/MRN encompass DNA damage sensor, and effector, and probably DNA-PKcs to the DNA damage sites and activating their functions, cell cycle checkpoint control and meiosis, maintenance of telomere integrity, signal transducer, which are provided by MRE11A, which enable cells to maintain DNA integrity and genomic stability, Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission:	625, 650nm/670nm
Synonyms:	ATV AT-V2 AT-V1
Properties:	Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	p95 NBS1 (Ser343) Conjugated
Short name:	Conjugated, p95 NBS1 (Ser343) Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Cy5
Alternative name:	cyanine 5 coupled, p95 NBS1 (Ser343) (Antibody to)
Alternative technique:	antibodies
Identity:	7652
Gene:	NBN | More about : NBN
Long gene name:	nibrin
Synonyms gene:	NBS NBS1
Synonyms gene name:	Nijmegen breakage syndrome 1 (nibrin)
Locus:	8q21, 3
Discovery year:	1997-11-28
GenBank acession:	AF058696
Entrez gene record:	4683
Pubmed identfication:	9590181 9590180
RefSeq identity:	NM_001024688
Classification:	BRCA1 C complex MRN complex
Havana BLAST/BLAT:	OTTHUMG00000153546
Locus Specific Databases:	LOVD - Leiden Open Variation Database LRG_158

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