| Long name: |
p95 NBS1 (Ser343) Primary Polyclonal Antibody |
| Also known as: |
p95 NBS1 (Ser343) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
p95 NBS1 Ser343 |
| Specificity: |
This is a highly specific antibody against p95 NBS1 Ser343 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser343 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
320-370/754 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human NBS1 around the phosphorylation site of Ser343 |
| Gene ID number: |
4683 |
| Swiss Prot: |
O60934 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ATR, DNA recombination, Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex, Forms a complex with RBBP8 to link DNA double-strand break sensing to resection, It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX, NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation, NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints, NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, RAD50 may be required to bind DNA ends and hold them in close proximity, The complex is involved in double-strand break (DSB) repair, The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, The roles of NBS1/MRN encompass DNA damage sensor, and effector, and probably DNA-PKcs to the DNA damage sites and activating their functions, cell cycle checkpoint control and meiosis, maintenance of telomere integrity, signal transducer, which are provided by MRE11A, which enable cells to maintain DNA integrity and genomic stability, Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AT-V1, AT-V2, Cell cycle regulatory protein p95, NBN, NBS, NBS1, Nibrin, Nijmegen breakage syndrome protein 1, P95, ATV |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
p95 NBS1 (Ser343) |
| Short name: |
p95 NBS1 (Ser343) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
p95 NBS1 (Ser343) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7652 |
| Gene: |
NBN |
More about : NBN |
| Long gene name: |
nibrin |
| Synonyms gene: |
NBS NBS1 |
| Synonyms gene name: |
Nijmegen breakage syndrome 1 (nibrin) |
| Synonyms: |
ATV AT-V2 AT-V1 |
| Locus: |
8q21, 3 |
| Discovery year: |
1997-11-28 |
| GenBank acession: |
AF058696 |
| Entrez gene record: |
4683 |
| Pubmed identfication: |
9590181 9590180 |
| RefSeq identity: |
NM_001024688 |
| Classification: |
BRCA1 C complex MRN complex |
| Havana BLAST/BLAT: |
OTTHUMG00000153546 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database LRG_158 |