| Long name: |
Cy3 Conjugated, p95 NBS1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
cy3 conjugation kit |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
p95 NBS1 |
| Specificity: |
This is a highly specific antibody against p95 NBS1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
700-754/754 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic peptide derived from human NBS1 |
| Gene ID number: |
4683 |
| Swiss Prot: |
O60934 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
ATR, DNA recombination, Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex, Forms a complex with RBBP8 to link DNA double-strand break sensing to resection, It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX, NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation, NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints, NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, RAD50 may be required to bind DNA ends and hold them in close proximity, The complex is involved in double-strand break (DSB) repair, The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, The roles of NBS1/MRN encompass DNA damage sensor, and effector, and probably DNA-PKcs to the DNA damage sites and activating their functions, cell cycle checkpoint control and meiosis, maintenance of telomere integrity, signal transducer, which are provided by MRE11A, which enable cells to maintain DNA integrity and genomic stability, Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
512, 550nm/570, 615nm |
| Synonyms: |
ATV AT-V2 AT-V1 |
| Properties: |
1 of the p95 NBS1 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
p95 NBS1 Conjugated |
| Short name: |
Conjugated, p95 NBS1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy3 |
| Alternative name: |
cyanine 3 coupled, p95 NBS1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7652 |
| Gene: |
NBN |
More about : NBN |
| Long gene name: |
nibrin |
| Synonyms gene: |
NBS NBS1 |
| Synonyms gene name: |
Nijmegen breakage syndrome 1 (nibrin) |
| Locus: |
8q21, 3 |
| Discovery year: |
1997-11-28 |
| GenBank acession: |
AF058696 |
| Entrez gene record: |
4683 |
| Pubmed identfication: |
9590181 9590180 |
| RefSeq identity: |
NM_001024688 |
| Classification: |
BRCA1 C complex MRN complex |
| Havana BLAST/BLAT: |
OTTHUMG00000153546 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database LRG_158 |