| Long name: |
ALEXA FLUOR 647 Conjugated, p95 NBS1 (Ser343) Polyclonal Antibody |
| Also known as: |
Anti-p95 NBS1 Ser343 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
p95 NBS1 Ser343 |
| Specificity: |
This is a highly specific antibody against p95 NBS1 Ser343 |
| Modification: |
Phosphorylation |
| Modification Site: |
Ser343 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
320-370/754 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human NBS1 around the phosphorylation site of Ser343 |
| Gene ID Number: |
4683 |
| Swiss Prot: |
O60934 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
ATR, DNA recombination, Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex, Forms a complex with RBBP8 to link DNA double-strand break sensing to resection, It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX, NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation, NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints, NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, RAD50 may be required to bind DNA ends and hold them in close proximity, The complex is involved in double-strand break (DSB) repair, The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, The roles of NBS1/MRN encompass DNA damage sensor, and effector, and probably DNA-PKcs to the DNA damage sites and activating their functions, cell cycle checkpoint control and meiosis, maintenance of telomere integrity, signal transducer, which are provided by MRE11A, which enable cells to maintain DNA integrity and genomic stability, Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
ATV AT-V2 AT-V1 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the p95 NBS1 (Ser343) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
p95 NBS1 (Ser343) |
| Short name: |
p95 NBS1 (Ser343) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, p95 NBS1 (Ser343) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7652 |
| Gene: |
NBN |
More about : NBN |
| Long gene name: |
nibrin |
| Synonyms gene: |
NBS NBS1 |
| Synonyms gene name: |
Nijmegen breakage syndrome 1 (nibrin) |
| Locus: |
8q21, 3 |
| Discovery year: |
1997-11-28 |
| GenBank acession: |
AF058696 |
| Entrez gene record: |
4683 |
| Pubmed identfication: |
9590181 9590180 |
| RefSeq identity: |
NM_001024688 |
| Classification: |
BRCA1 C complex MRN complex |
| Havana BLAST/BLAT: |
OTTHUMG00000153546 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database LRG_158 |