| Long name: |
FITC Conjugated, TAK1(Thr184 + Thr187) Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
TAK1 Thr184 + Thr187 |
| Specificity: |
This is a highly specific antibody against TAK1 Thr184 + Thr187 |
| Modification: |
Phosphorylation |
| Modification site: |
Thr184 + Thr187 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
170-192/605 |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human TAK1 around the phosphorylation site of Thr184/187 |
| Gene ID number: |
6885 |
| Swiss Prot: |
O43318 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), Ceramides are also able to activate MAP3K7/TAK1, In osmotic stress signaling, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7, MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis, Mediates signal transduction of TRAF6, Once activated, Plays an important role in the cascades of cellular responses evoked by changes in the environment, Promotes TRIM5 capsid-specific restriction activity, TGFB-related factors like BMP2 and BMP4, These MAP2Ks in turn activate p38 MAPKs, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, but not that of NF-kappa-B, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK), plays a major role in the activation of MAPK8/JNK1, toll-like receptors (TLR), transforming growth factor-beta (TGFB), tumor necrosis factor receptor CD40 and B-cell receptor (BCR), various cytokines including interleukin-1 (IL-1), while nuclear factor-kappa B is activated by IKK, Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
MEKK7 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TAK1(Thr184 + Thr187) Conjugated |
| Short name: |
FITC Conjugated, TAK1(Thr184 + Thr187) Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, TAK1(Thr184 and Thr187) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6859 |
| Gene: |
MAP3K7 |
More about : MAP3K7 |
| Long gene name: |
mitogen-activated protein kinase kinase kinase 7 |
| Synonyms gene: |
TAK1 |
| Synonyms name: |
TGF-beta activated kinase 1 |
| Locus: |
6q15 |
| Discovery year: |
1998-05-22 |
| GenBank acession: |
AB009356 |
| Entrez gene record: |
6885 |
| Pubmed identfication: |
9466656 |
| RefSeq identity: |
NM_145331 |
| Classification: |
Mitogen-activated protein kinase kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000015217 |
| Locus Specific Databases: |
The Globin Gene Server |