| Long name: |
TAK1(Thr184 + Thr187) Antibody |
| Also known as: |
TAK1(Thr184 + Thr187) Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TAK1 Thr184 + Thr187 |
| Specificity: |
This is a highly specific antibody against TAK1 Thr184 + Thr187 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Thr184 + Thr187 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
170-192/605 |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human TAK1 around the phosphorylation site of Thr184/187 |
| Gene ID number: |
6885 |
| Swiss Prot: |
O43318 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), Ceramides are also able to activate MAP3K7/TAK1, In osmotic stress signaling, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7, MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis, Mediates signal transduction of TRAF6, Once activated, Plays an important role in the cascades of cellular responses evoked by changes in the environment, Promotes TRIM5 capsid-specific restriction activity, TGFB-related factors like BMP2 and BMP4, These MAP2Ks in turn activate p38 MAPKs, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, but not that of NF-kappa-B, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK), plays a major role in the activation of MAPK8/JNK1, toll-like receptors (TLR), transforming growth factor-beta (TGFB), tumor necrosis factor receptor CD40 and B-cell receptor (BCR), various cytokines including interleukin-1 (IL-1), while nuclear factor-kappa B is activated by IKK, Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
MAP3K7, MEKK7, Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1, TGF1a, Transforming growth factor-beta-activated kinase 1, TAK1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TAK1(Thr184 + Thr187) |
| Short name: |
TAK1(Thr184 + Thr187) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TAK1(Thr184 and Thr187) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6859 |
| Gene: |
MAP3K7 |
More about : MAP3K7 |
| Long gene name: |
mitogen-activated protein kinase kinase kinase 7 |
| Synonyms gene: |
TAK1 |
| Synonyms: |
MEKK7 |
| Synonyms name: |
TGF-beta activated kinase 1 |
| Locus: |
6q15 |
| Discovery year: |
1998-05-22 |
| GenBank acession: |
AB009356 |
| Entrez gene record: |
6885 |
| Pubmed identfication: |
9466656 |
| RefSeq identity: |
NM_145331 |
| Classification: |
Mitogen-activated protein kinase kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000015217 |
| Locus Specific Databases: |
The Globin Gene Server |