Smad2(Ser465 + Ser467) Antibody

Catalog number:	bs-3419R Buy Now
Price:	370 €
Supplier:	MBS Polyclonals_1
Product name:	Smad2(Ser465 + Ser467) Antibody
Quantity:	100ug
Related search:	smad ser antibody antibodies mad erk

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Long name:	Smad2(Ser465 + Ser467) Antibody
Also known as:	Smad2(Ser465 + Ser467) Antibody
Category:	Primary Antibodies
Conjugation:	Unconjugated
Target Antigen:	Smad2 Ser465 + Ser467
Specificity:	This is a highly specific antibody against Smad2 Ser465 + Ser467
Modification(s):	Phosphorylation
Modification site(s):	Ser465 + Ser467
Clonality:	Polyclonal antibody
Clone number:	Polyclonal antibody
Concentration:	1ug per 1ul
Source:	KLH conjugated synthetic phosphopeptide derived from human SMAD2 around the phosphorylation site of Ser465/467
Gene ID number:	4087
Tested Applications:	IF(IHC-P), IHC-P, WB
Recommended dilutions:	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity:	Mouse, Rat, Human
Cross reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen:	(Smad4) that functions via its interaction to the various Smad's, (Smad6 and Smad7), 5, Activated Smad2 associates with Smad4 and translocates as a complex into the nucleus, Phosphorylation of threonine 8 in the calmodulin binding region of the MH1 domain by extracellular signal regulated kinase 1(ERK 1) enhances Smad2 transcriptional activity, Smad2 consists of two highly conserved domains, The MH1 domain binds DNA and regulates nuclear import and transcription while the MH2 domain conserved among all the Smad's regulates Smad2 oligomerization and binding to cytoplasmic adaptors and transcription factors, The Smad family is divided into three subclasses: receptor-regulated Smad's, The regulation of Smad2 phosphorylation on threonine 8 by ERK 1 and calmodulin is critical for Smad2 mediated signaling, This translocation of Smad2 (as well as Smad3) into the nucleus is a central event in TGF beta signaling, activin/TGF alpha receptor-regulated (Smad2 and 3) or BMP receptor regulated (Smad1, allowing its binding to DNA and transcription factors, and 8), and the inhibitory Smad's, differentiation and development, the N terminal Mad homology (MH1) and the C-terminal Mad homology 2 (MH2) domains, the common partner, which is negatively regulated by calmodulin, Smad2 is a 58 kDa member of a family of proteins involved in cell proliferation
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names:	JV18, JV18 1, JV181, MAD, MAD Related Protein 2, MADH2, MADR2, MGC22139, MGC34440, Mothers Against Decapentaplegic Homolog 2, SMAD, SMAD 2, SMAD2, SMAD2_HUMAN, Smad2p-S465/467, hMAD 2, hSMAD2, mothers against DPP homolog 2, p-Smad2Ser465/467, Smad2p-Ser465/467
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target:	Smad2(Ser465 + Ser467)
Short name:	Smad2(Ser465 + Ser467) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Alternative name:	SMAD family member 2(Ser465 and Ser467) (Antibody to)
Alternative technique:	antibodies

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